Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro

Malgorzata Kamocka, Marek Rózalski, Urszula Krajewska, Ryszard Wierzbicki, Wojciech P. Mielicki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cancer procoagulant (CP) is a cysteine protease produced by fetal and malignant tissues, activating in vitro blood coagulation factor X. It has been demonstrated that CP is able to stimulate blood platelet adhesion to fibrinogen and collagen. The pro-adhesive properties of CP could play an important role in metastatic spread of cancer as well as in primary tumor growth. Effects of anti-CP antibody on the growth of MCF-7 breast cancer cells and on the cells adhesion to vitronectin have been analyzed in vitro. Addition of polyclonal anti-CP antibody to MCF-7 cell culture resulted in 16-18% (P

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalCancer Letters
Volume222
Issue number1
DOIs
StatePublished - May 10 2005
Externally publishedYes

Fingerprint

cancer procoagulant
Vitronectin
MCF-7 Cells
Growth
Factor X
Cysteine Proteases
Antibodies
Cell Adhesion
Adhesives
Fibrinogen
Neoplasms
Fetus
Collagen
Blood Platelets
Cell Culture Techniques
In Vitro Techniques
Breast Neoplasms

Keywords

  • Cancer procoagulant
  • Cell adhesion
  • MCF-7
  • Vitronectin

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro. / Kamocka, Malgorzata; Rózalski, Marek; Krajewska, Urszula; Wierzbicki, Ryszard; Mielicki, Wojciech P.

In: Cancer Letters, Vol. 222, No. 1, 10.05.2005, p. 89-94.

Research output: Contribution to journalArticle

Kamocka, Malgorzata ; Rózalski, Marek ; Krajewska, Urszula ; Wierzbicki, Ryszard ; Mielicki, Wojciech P. / Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro. In: Cancer Letters. 2005 ; Vol. 222, No. 1. pp. 89-94.
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