Effect of capillary pressure and lung distension on capillary recruitment

P. S. Godbey, J. A. Graham, Robert Presson, W. W. Wagner, T. C. Lloyd

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To investigate the effect of capillary pressure and alveolar distension on capillary recruitment, we used video-microscopy to quantify capillary recruitment in individual subpleural alveolar walls. Canine lobes were perfused with autologous blood either while inflated by positive airway pressure or while inflated by negative intrapleural pressure in the intact thorax with airway pressure remaining atmospheric. Low flow rates minimized the arteriovenous pressure gradient (<5 mmHg), permitting capillary pressure estimation by averaging these pressures. Capillary pressure was varied stepwise from airway pressure to 30 mmHg above airway pressure. Capillary recruitment always began as capillary pressure exceeded airway pressure. At low positive airway pressures, the capillaries of the excised lobes opened suddenly over a narrow pressure range. At higher airway pressures and in the intact thorax, recruitment occurred over a wide range of capillary pressures. We conclude that capillary perfusion begins when intracapillary pressure just exceeds alveolar pressure but that further increases in capillary pressure recruit capillaries depending on tension in the alveolar wall, whether imposed by positive airway pressure or by gravity when the lung is suspended in an intact thorax.

Original languageEnglish
Pages (from-to)1142-1147
Number of pages6
JournalJournal of Applied Physiology
Volume79
Issue number4
StatePublished - 1995

Fingerprint

Pressure
Lung
Thorax
Video Microscopy
Atmospheric Pressure
Gravitation
Canidae
Perfusion

Keywords

  • airway pressure
  • alveolar size
  • dogs
  • plasma markers
  • pulmonary capillary recruitment
  • sheet flow
  • videomicroscopy

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Godbey, P. S., Graham, J. A., Presson, R., Wagner, W. W., & Lloyd, T. C. (1995). Effect of capillary pressure and lung distension on capillary recruitment. Journal of Applied Physiology, 79(4), 1142-1147.

Effect of capillary pressure and lung distension on capillary recruitment. / Godbey, P. S.; Graham, J. A.; Presson, Robert; Wagner, W. W.; Lloyd, T. C.

In: Journal of Applied Physiology, Vol. 79, No. 4, 1995, p. 1142-1147.

Research output: Contribution to journalArticle

Godbey, PS, Graham, JA, Presson, R, Wagner, WW & Lloyd, TC 1995, 'Effect of capillary pressure and lung distension on capillary recruitment', Journal of Applied Physiology, vol. 79, no. 4, pp. 1142-1147.
Godbey, P. S. ; Graham, J. A. ; Presson, Robert ; Wagner, W. W. ; Lloyd, T. C. / Effect of capillary pressure and lung distension on capillary recruitment. In: Journal of Applied Physiology. 1995 ; Vol. 79, No. 4. pp. 1142-1147.
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