Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET

A. Buck, H. G. Wolpers, Gary Hutchins, V. Savas, T. J. Mangner, N. Nguyen, M. Schwaiger

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.

Original languageEnglish (US)
Pages (from-to)1950-1957
Number of pages8
JournalJournal of Nuclear Medicine
Volume32
Issue number10
StatePublished - 1991
Externally publishedYes

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Oxygen Consumption
Pressure
Intravenous Injections
carbon-11 acetate
Thorax
Dogs

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Buck, A., Wolpers, H. G., Hutchins, G., Savas, V., Mangner, T. J., Nguyen, N., & Schwaiger, M. (1991). Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. Journal of Nuclear Medicine, 32(10), 1950-1957.

Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. / Buck, A.; Wolpers, H. G.; Hutchins, Gary; Savas, V.; Mangner, T. J.; Nguyen, N.; Schwaiger, M.

In: Journal of Nuclear Medicine, Vol. 32, No. 10, 1991, p. 1950-1957.

Research output: Contribution to journalArticle

Buck, A, Wolpers, HG, Hutchins, G, Savas, V, Mangner, TJ, Nguyen, N & Schwaiger, M 1991, 'Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET', Journal of Nuclear Medicine, vol. 32, no. 10, pp. 1950-1957.
Buck, A. ; Wolpers, H. G. ; Hutchins, Gary ; Savas, V. ; Mangner, T. J. ; Nguyen, N. ; Schwaiger, M. / Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. In: Journal of Nuclear Medicine. 1991 ; Vol. 32, No. 10. pp. 1950-1957.
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AU - Buck, A.

AU - Wolpers, H. G.

AU - Hutchins, Gary

AU - Savas, V.

AU - Mangner, T. J.

AU - Nguyen, N.

AU - Schwaiger, M.

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N2 - Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.

AB - Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.

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