Effect of Carbon Dioxide on the Twinkling Artifact in Ultrasound Imaging of Kidney Stones: A Pilot Study

Julianna C. Simon, Yak Nam Wang, Bryan W. Cunitz, Jeffrey Thiel, Frank Starr, Ziyue Liu, Michael R. Bailey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound "twinkling artifact," which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0.8% carbon dioxide. On exposure of the pigs to 0.8% carbon dioxide, twinkling was significantly reduced after 9-25 min and recovered when the carrier gas returned to oxygen. These trends repeated when pigs were again exposed to 0.8% carbon dioxide followed by oxygen. The reduction of twinkling caused by exposure to elevated carbon dioxide may make kidney stone detection with twinkling difficult in current space vehicles.

Original languageEnglish (US)
JournalUltrasound in Medicine and Biology
DOIs
StateAccepted/In press - Oct 1 2016

Fingerprint

kidney stones
Kidney Calculi
Carbon Dioxide
Artifacts
artifacts
carbon dioxide
Ultrasonography
swine
Swine
Oxygen
bone demineralization
spacecraft
oxygen
Color
rocks
Astronauts
anesthetics
Inhalation Anesthetics
color
Microbubbles

Keywords

  • Bubbles
  • Carbon dioxide
  • Doppler
  • Kidney stones
  • Space
  • Twinkling artifact
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of Carbon Dioxide on the Twinkling Artifact in Ultrasound Imaging of Kidney Stones : A Pilot Study. / Simon, Julianna C.; Wang, Yak Nam; Cunitz, Bryan W.; Thiel, Jeffrey; Starr, Frank; Liu, Ziyue; Bailey, Michael R.

In: Ultrasound in Medicine and Biology, 01.10.2016.

Research output: Contribution to journalArticle

Simon, Julianna C. ; Wang, Yak Nam ; Cunitz, Bryan W. ; Thiel, Jeffrey ; Starr, Frank ; Liu, Ziyue ; Bailey, Michael R. / Effect of Carbon Dioxide on the Twinkling Artifact in Ultrasound Imaging of Kidney Stones : A Pilot Study. In: Ultrasound in Medicine and Biology. 2016.
@article{9b4a1721e0bb43539ad836fddc73d05a,
title = "Effect of Carbon Dioxide on the Twinkling Artifact in Ultrasound Imaging of Kidney Stones: A Pilot Study",
abstract = "Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound {"}twinkling artifact,{"} which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0.8{\%} carbon dioxide. On exposure of the pigs to 0.8{\%} carbon dioxide, twinkling was significantly reduced after 9-25 min and recovered when the carrier gas returned to oxygen. These trends repeated when pigs were again exposed to 0.8{\%} carbon dioxide followed by oxygen. The reduction of twinkling caused by exposure to elevated carbon dioxide may make kidney stone detection with twinkling difficult in current space vehicles.",
keywords = "Bubbles, Carbon dioxide, Doppler, Kidney stones, Space, Twinkling artifact, Ultrasound",
author = "Simon, {Julianna C.} and Wang, {Yak Nam} and Cunitz, {Bryan W.} and Jeffrey Thiel and Frank Starr and Ziyue Liu and Bailey, {Michael R.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.ultrasmedbio.2016.12.010",
language = "English (US)",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Effect of Carbon Dioxide on the Twinkling Artifact in Ultrasound Imaging of Kidney Stones

T2 - A Pilot Study

AU - Simon, Julianna C.

AU - Wang, Yak Nam

AU - Cunitz, Bryan W.

AU - Thiel, Jeffrey

AU - Starr, Frank

AU - Liu, Ziyue

AU - Bailey, Michael R.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound "twinkling artifact," which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0.8% carbon dioxide. On exposure of the pigs to 0.8% carbon dioxide, twinkling was significantly reduced after 9-25 min and recovered when the carrier gas returned to oxygen. These trends repeated when pigs were again exposed to 0.8% carbon dioxide followed by oxygen. The reduction of twinkling caused by exposure to elevated carbon dioxide may make kidney stone detection with twinkling difficult in current space vehicles.

AB - Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound "twinkling artifact," which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0.8% carbon dioxide. On exposure of the pigs to 0.8% carbon dioxide, twinkling was significantly reduced after 9-25 min and recovered when the carrier gas returned to oxygen. These trends repeated when pigs were again exposed to 0.8% carbon dioxide followed by oxygen. The reduction of twinkling caused by exposure to elevated carbon dioxide may make kidney stone detection with twinkling difficult in current space vehicles.

KW - Bubbles

KW - Carbon dioxide

KW - Doppler

KW - Kidney stones

KW - Space

KW - Twinkling artifact

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85012882675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012882675&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2016.12.010

DO - 10.1016/j.ultrasmedbio.2016.12.010

M3 - Article

C2 - 28190622

AN - SCOPUS:85012882675

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

ER -