Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure.

Ying Xue Dong, John C. Burnett, Horng H. Chen, Sharon Sandberg, Yan Zhong Yang, Yanhua Zhang, Peng-Sheng Chen, Yong Mei Cha

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neurohormonal dysregulation contributes to heart failure (HF) progression. We sought to determine the effect of cardiac resynchronization therapy (CRT) on nerve growth factor (NGF), a biomarker that promotes the maturation and survival of sympathetic nerve endings, and amino-terminal propeptide of type III procollagen (PIIINP), a marker of type III collagen synthesis. This prospective study consisted of 45 consecutive patients who received cardiac resynchronization therapy defibrillator for advanced HF and 20 healthy age-matched controls. New York Heart Association class, distance of 6-min walk, echocardiography and plasma concentrations of NGF, PIIINP, b-type natriuretic peptide (BNP), norepinephrine, and epinephrine were measured before and 6 months after CRT. Response to CRT was defined as 15% or greater reduction in left ventricular end-systolic volume index at 6-month follow-up. The baseline BNP (2.61±0.51 vs. 1.53±0.44 ug/L, P

Original languageEnglish (US)
Pages (from-to)241-249
Number of pages9
JournalJournal of Interventional Cardiac Electrophysiology
Volume30
Issue number3
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Cardiac Resynchronization Therapy
Neurotransmitter Agents
Heart Failure
Biomarkers
Natriuretic Peptides
Collagen Type III
Nerve Growth Factor
Defibrillators
Nerve Endings
Stroke Volume
Epinephrine
Echocardiography
Norepinephrine
Prospective Studies
procollagen Type III-N-terminal peptide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure. / Dong, Ying Xue; Burnett, John C.; Chen, Horng H.; Sandberg, Sharon; Yang, Yan Zhong; Zhang, Yanhua; Chen, Peng-Sheng; Cha, Yong Mei.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 30, No. 3, 04.2011, p. 241-249.

Research output: Contribution to journalArticle

Dong, Ying Xue ; Burnett, John C. ; Chen, Horng H. ; Sandberg, Sharon ; Yang, Yan Zhong ; Zhang, Yanhua ; Chen, Peng-Sheng ; Cha, Yong Mei. / Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure. In: Journal of Interventional Cardiac Electrophysiology. 2011 ; Vol. 30, No. 3. pp. 241-249.
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