Effect of cholestyramine and colestipol on the absorption of phenytoin

J. T. Callaghan, M. Tsuru, J. L. Holtzman, D. B. Hunninghake

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume24
Issue number5
DOIs
StatePublished - Sep 1 1983
Externally publishedYes

Keywords

  • cholestyramine
  • clearance
  • colestipol
  • phenytoin absorption

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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