Effect of cholestyramine and colestipol on the absorption of phenytoin

John Callaghan, M. Tsuru, J. L. Holtzman, D. B. Hunninghake

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume24
Issue number5
DOIs
StatePublished - Sep 1983
Externally publishedYes

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Colestipol
Cholestyramine Resin
Phenytoin
Anions
Cations
Volunteers
Pharmaceutical Preparations

Keywords

  • cholestyramine
  • clearance
  • colestipol
  • phenytoin absorption

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Effect of cholestyramine and colestipol on the absorption of phenytoin. / Callaghan, John; Tsuru, M.; Holtzman, J. L.; Hunninghake, D. B.

In: European Journal of Clinical Pharmacology, Vol. 24, No. 5, 09.1983, p. 675-678.

Research output: Contribution to journalArticle

Callaghan, John ; Tsuru, M. ; Holtzman, J. L. ; Hunninghake, D. B. / Effect of cholestyramine and colestipol on the absorption of phenytoin. In: European Journal of Clinical Pharmacology. 1983 ; Vol. 24, No. 5. pp. 675-678.
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