Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence

F. Pizzarelli, Munro Peacock

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Urine alkalinization favours the formation of calcium phosphate (CaP) and struvite stones. In this retrospective study we analyze the effect of chronic urinary acidification on phosphatic stone recurrence. Twenty-four patients with CaP-struvite recurrent stones and persistently high urinary pH were divided in two groups: group A, 11 patients who failed to lower the urinary pH below 5.5 during a standard acid load test; group B, 13 patients with preserved acidification power. Ammonium sulfate 2-3 g/day was given 4.7 and 6.5 years to groups A and B, respectively. A persistent reduction in urinary pH, relative saturation for CaP and stone formation rate was observed in both groups. The treatment did not cause systemic acidosis as long as renal function remained normal. Urinary daily excretion of Ca and P as well as their renal tubular handlings did not change with time. Results suggest acidifying agents might be useful in preventing recurrence of CaP-struvite stones even in the presence of a mild acidification defect and encourage undertaking properly controlled prospective trials.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalNephron
Volume46
Issue number3
StatePublished - 1987
Externally publishedYes

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Ammonium Sulfate
Recurrence
Kidney
Acidosis
Retrospective Studies
Urine
Acids
calcium phosphate
Struvite
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence. / Pizzarelli, F.; Peacock, Munro.

In: Nephron, Vol. 46, No. 3, 1987, p. 247-252.

Research output: Contribution to journalArticle

Pizzarelli, F & Peacock, M 1987, 'Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence', Nephron, vol. 46, no. 3, pp. 247-252.
Pizzarelli, F. ; Peacock, Munro. / Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence. In: Nephron. 1987 ; Vol. 46, No. 3. pp. 247-252.
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