Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence

F. Pizzarelli, M. Peacock

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Urine alkalinization favours the formation of calcium phosphate (CaP) and struvite stones. In this retrospective study we analyze the effect of chronic urinary acidification on phosphatic stone recurrence. Twenty-four patients with CaP-struvite recurrent stones and persistently high urinary pH were divided in two groups: group A, 11 patients who failed to lower the urinary pH below 5.5 during a standard acid load test; group B, 13 patients with preserved acidification power. Ammonium sulfate 2-3 g/day was given 4.7 and 6.5 years to groups A and B, respectively. A persistent reduction in urinary pH, relative saturation for CaP and stone formation rate was observed in both groups. The treatment did not cause systemic acidosis as long as renal function remained normal. Urinary daily excretion of Ca and P as well as their renal tubular handlings did not change with time. Results suggest acidifying agents might be useful in preventing recurrence of CaP-struvite stones even in the presence of a mild acidification defect and encourage undertaking properly controlled prospective trials.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalNephron
Volume46
Issue number3
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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