Effect of chronic fluoride exposure in uremic rats

Ann Dunipace, Edward Brizendine, Marie Wilson, Wu Zhang, Cynthia Wilson, Barry Katz, Abdel Kafrawy, George Stookey

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insufficiency result in toxic fluoride effects not ordinarily observed in healthy animals. Uremic and sham-operated control rats received 0 μg/ml, 5 (0.26 mmol/l), 15 (0.79), or 50 μg/ml (2.63 mmol/l) of fluoride in their drinking water for 3 or 6 months. Fluoride retention was monitored, and, following euthanasia, tissue fluoride and biochemical, markers of tissue function were analyzed. Selected tissues were saved for histology, and bone marrow cells were harvested for determining the frequency of sister chromatid exchange, a marker of genetic damage. In spite of significantly higher levels of fluoride in the tissues of the animals with renal insufficiency, there were no clinically adverse, fluoride-induced, extraskeletal physiological, biochemical, or genetic effects of chronic exposure to common levels of fluoride in these rats.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalNephron
Volume78
Issue number1
DOIs
StatePublished - Jan 12 1998

Keywords

  • Fluoride metabolism
  • Fluoride toxicity
  • Renal insufficiency, fluoride metabolism

ASJC Scopus subject areas

  • Nephrology

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