Effect of Collaborative Telerehabilitation on Functional Impairment and Pain among Patients with Advanced-Stage Cancer: A Randomized Clinical Trial

Andrea L. Cheville, Timothy Moynihan, Jeph Herrin, Charles Loprinzi, Kurt Kroenke

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Importance: Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. Objective: To determine whether collaborative telerehabilitation and pharmacological pain management improve function, lessen pain, and reduce requirements for inpatient care. Design, Setting, and Patients: The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic medical centers within 1 health care system. Patient recruitment began in March 2013 and follow-up concluded in October 2016. Participants (N = 516) were low-level community or household ambulators with stage IIIC or IV solid or hematologic cancer. Interventions: Participants were randomly assigned to the (1) control arm, (2) telerehabilitation arm, or (3) telerehabilitation with pharmacological pain management arm. All patients underwent automated function and pain monitoring with data reporting to their care teams. Participants in arms 2 and 3 received 6 months of centralized telerehabilitation provided by a physical therapist-physician team. Those in arm 3 also received nurse-coordinated pharmacological pain management. Main Outcomes and Measures: Blinded assessment of function using the Activity Measure for Postacute Care computer adaptive test, pain interference and average intensity using the Brief Pain Inventory, and quality of life using the EQ-5D-3L was performed at baseline and months 3 and 6. Hospitalizations and discharges to postacute care facilities were recorded. Results: The study included 516 participants (257 women and 259 men; mean [SD] age, 65.6 [11.1] years), with 172 randomized to 1 of 3 arms. Compared with the control group, the telerehabilitation arm 2 had improved function (difference, 1.3; 95% CI, 0.08-2.35; P =.03) and quality of life (difference, 0.04; 95% CI, 0.004-0.071; P =.01), while both telerehabilitation arms 2 and 3 had reduced pain interference (arm 2, -0.4; 95% CI, -0.78 to -0.09; P =.01 and arm 3, -0.4; 95% CI, -0.79 to -0.10; P =.01), and average intensity (arm 2, -0.4; 95% CI, -0.78 to -0.07; P =.02 and arm 3, -0.5; 95% CI, -0.84 to -0.11; P =.006). Telerehabilitation was associated with higher odds of home discharge in arms 2 (odds ratio [OR], 4.3; 95% CI, 1.3-14.3; P =.02) and 3 (OR, 3.8; 95% CI, 1.1-12.4; P =.03) and fewer days in the hospital in arm 2 (difference, -3.9 days; 95% CI, -2.4 to -4.6; P =.01). Conclusions and Relevance: Collaborative telerehabilitation modestly improved function and pain, while decreasing hospital length of stay and the requirement for postacute care, but these outcomes were not enhanced with the addition of pharmacological pain management. Trial Registration: ClinicalTrials.gov identifier: NCT01721343..

Original languageEnglish (US)
JournalJAMA Oncology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Randomized Controlled Trials
Pain
Subacute Care
Pain Management
Neoplasms
Pharmacology
Length of Stay
Odds Ratio
Quality of Life
Telerehabilitation
Physical Therapists
Patient Selection
Inpatients
Hospitalization
Research Design
Nurses
Outcome Assessment (Health Care)
Delivery of Health Care
Physicians
Equipment and Supplies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Effect of Collaborative Telerehabilitation on Functional Impairment and Pain among Patients with Advanced-Stage Cancer : A Randomized Clinical Trial. / Cheville, Andrea L.; Moynihan, Timothy; Herrin, Jeph; Loprinzi, Charles; Kroenke, Kurt.

In: JAMA Oncology, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Importance: Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. Objective: To determine whether collaborative telerehabilitation and pharmacological pain management improve function, lessen pain, and reduce requirements for inpatient care. Design, Setting, and Patients: The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic medical centers within 1 health care system. Patient recruitment began in March 2013 and follow-up concluded in October 2016. Participants (N = 516) were low-level community or household ambulators with stage IIIC or IV solid or hematologic cancer. Interventions: Participants were randomly assigned to the (1) control arm, (2) telerehabilitation arm, or (3) telerehabilitation with pharmacological pain management arm. All patients underwent automated function and pain monitoring with data reporting to their care teams. Participants in arms 2 and 3 received 6 months of centralized telerehabilitation provided by a physical therapist-physician team. Those in arm 3 also received nurse-coordinated pharmacological pain management. Main Outcomes and Measures: Blinded assessment of function using the Activity Measure for Postacute Care computer adaptive test, pain interference and average intensity using the Brief Pain Inventory, and quality of life using the EQ-5D-3L was performed at baseline and months 3 and 6. Hospitalizations and discharges to postacute care facilities were recorded. Results: The study included 516 participants (257 women and 259 men; mean [SD] age, 65.6 [11.1] years), with 172 randomized to 1 of 3 arms. Compared with the control group, the telerehabilitation arm 2 had improved function (difference, 1.3; 95{\%} CI, 0.08-2.35; P =.03) and quality of life (difference, 0.04; 95{\%} CI, 0.004-0.071; P =.01), while both telerehabilitation arms 2 and 3 had reduced pain interference (arm 2, -0.4; 95{\%} CI, -0.78 to -0.09; P =.01 and arm 3, -0.4; 95{\%} CI, -0.79 to -0.10; P =.01), and average intensity (arm 2, -0.4; 95{\%} CI, -0.78 to -0.07; P =.02 and arm 3, -0.5; 95{\%} CI, -0.84 to -0.11; P =.006). Telerehabilitation was associated with higher odds of home discharge in arms 2 (odds ratio [OR], 4.3; 95{\%} CI, 1.3-14.3; P =.02) and 3 (OR, 3.8; 95{\%} CI, 1.1-12.4; P =.03) and fewer days in the hospital in arm 2 (difference, -3.9 days; 95{\%} CI, -2.4 to -4.6; P =.01). Conclusions and Relevance: Collaborative telerehabilitation modestly improved function and pain, while decreasing hospital length of stay and the requirement for postacute care, but these outcomes were not enhanced with the addition of pharmacological pain management. Trial Registration: ClinicalTrials.gov identifier: NCT01721343..",
author = "Cheville, {Andrea L.} and Timothy Moynihan and Jeph Herrin and Charles Loprinzi and Kurt Kroenke",
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T1 - Effect of Collaborative Telerehabilitation on Functional Impairment and Pain among Patients with Advanced-Stage Cancer

T2 - A Randomized Clinical Trial

AU - Cheville, Andrea L.

AU - Moynihan, Timothy

AU - Herrin, Jeph

AU - Loprinzi, Charles

AU - Kroenke, Kurt

PY - 2019/1/1

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N2 - Importance: Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. Objective: To determine whether collaborative telerehabilitation and pharmacological pain management improve function, lessen pain, and reduce requirements for inpatient care. Design, Setting, and Patients: The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic medical centers within 1 health care system. Patient recruitment began in March 2013 and follow-up concluded in October 2016. Participants (N = 516) were low-level community or household ambulators with stage IIIC or IV solid or hematologic cancer. Interventions: Participants were randomly assigned to the (1) control arm, (2) telerehabilitation arm, or (3) telerehabilitation with pharmacological pain management arm. All patients underwent automated function and pain monitoring with data reporting to their care teams. Participants in arms 2 and 3 received 6 months of centralized telerehabilitation provided by a physical therapist-physician team. Those in arm 3 also received nurse-coordinated pharmacological pain management. Main Outcomes and Measures: Blinded assessment of function using the Activity Measure for Postacute Care computer adaptive test, pain interference and average intensity using the Brief Pain Inventory, and quality of life using the EQ-5D-3L was performed at baseline and months 3 and 6. Hospitalizations and discharges to postacute care facilities were recorded. Results: The study included 516 participants (257 women and 259 men; mean [SD] age, 65.6 [11.1] years), with 172 randomized to 1 of 3 arms. Compared with the control group, the telerehabilitation arm 2 had improved function (difference, 1.3; 95% CI, 0.08-2.35; P =.03) and quality of life (difference, 0.04; 95% CI, 0.004-0.071; P =.01), while both telerehabilitation arms 2 and 3 had reduced pain interference (arm 2, -0.4; 95% CI, -0.78 to -0.09; P =.01 and arm 3, -0.4; 95% CI, -0.79 to -0.10; P =.01), and average intensity (arm 2, -0.4; 95% CI, -0.78 to -0.07; P =.02 and arm 3, -0.5; 95% CI, -0.84 to -0.11; P =.006). Telerehabilitation was associated with higher odds of home discharge in arms 2 (odds ratio [OR], 4.3; 95% CI, 1.3-14.3; P =.02) and 3 (OR, 3.8; 95% CI, 1.1-12.4; P =.03) and fewer days in the hospital in arm 2 (difference, -3.9 days; 95% CI, -2.4 to -4.6; P =.01). Conclusions and Relevance: Collaborative telerehabilitation modestly improved function and pain, while decreasing hospital length of stay and the requirement for postacute care, but these outcomes were not enhanced with the addition of pharmacological pain management. Trial Registration: ClinicalTrials.gov identifier: NCT01721343..

AB - Importance: Most patients with advanced-stage cancer develop impairment and pain-driven functional losses that jeopardize their independence. Objective: To determine whether collaborative telerehabilitation and pharmacological pain management improve function, lessen pain, and reduce requirements for inpatient care. Design, Setting, and Patients: The Collaborative Care to Preserve Performance in Cancer (COPE) study was a 3-arm randomized clinical trial conducted at 3 academic medical centers within 1 health care system. Patient recruitment began in March 2013 and follow-up concluded in October 2016. Participants (N = 516) were low-level community or household ambulators with stage IIIC or IV solid or hematologic cancer. Interventions: Participants were randomly assigned to the (1) control arm, (2) telerehabilitation arm, or (3) telerehabilitation with pharmacological pain management arm. All patients underwent automated function and pain monitoring with data reporting to their care teams. Participants in arms 2 and 3 received 6 months of centralized telerehabilitation provided by a physical therapist-physician team. Those in arm 3 also received nurse-coordinated pharmacological pain management. Main Outcomes and Measures: Blinded assessment of function using the Activity Measure for Postacute Care computer adaptive test, pain interference and average intensity using the Brief Pain Inventory, and quality of life using the EQ-5D-3L was performed at baseline and months 3 and 6. Hospitalizations and discharges to postacute care facilities were recorded. Results: The study included 516 participants (257 women and 259 men; mean [SD] age, 65.6 [11.1] years), with 172 randomized to 1 of 3 arms. Compared with the control group, the telerehabilitation arm 2 had improved function (difference, 1.3; 95% CI, 0.08-2.35; P =.03) and quality of life (difference, 0.04; 95% CI, 0.004-0.071; P =.01), while both telerehabilitation arms 2 and 3 had reduced pain interference (arm 2, -0.4; 95% CI, -0.78 to -0.09; P =.01 and arm 3, -0.4; 95% CI, -0.79 to -0.10; P =.01), and average intensity (arm 2, -0.4; 95% CI, -0.78 to -0.07; P =.02 and arm 3, -0.5; 95% CI, -0.84 to -0.11; P =.006). Telerehabilitation was associated with higher odds of home discharge in arms 2 (odds ratio [OR], 4.3; 95% CI, 1.3-14.3; P =.02) and 3 (OR, 3.8; 95% CI, 1.1-12.4; P =.03) and fewer days in the hospital in arm 2 (difference, -3.9 days; 95% CI, -2.4 to -4.6; P =.01). Conclusions and Relevance: Collaborative telerehabilitation modestly improved function and pain, while decreasing hospital length of stay and the requirement for postacute care, but these outcomes were not enhanced with the addition of pharmacological pain management. Trial Registration: ClinicalTrials.gov identifier: NCT01721343..

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