Effect of continuous positive airway pressure on forced expiratory flows in infants with tracheomalacia

S. Davis, M. Jones, J. Kisling, C. Angelicchio, R. S. Tepper

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Continuous positive airway pressure (CPAP) is used to minimize airway collapse in infants with tracheomalacia. Forced expiratory flows (FEFs) at functional residual capacity (FRC) increase with increasing CPAP in infants with tracheomalacia, and it has been suggested that CPAP prevents airway collapse by 'stenting' the airway open. Since FEF is greater at higher than at lower lung volumes, we evaluated whether the increase in flow measured at FRC (V(FRC)) with CPAP could be explained by the increase in FRC with CPAP. We measured full FEF-volume curves at CPAP levels of 0, 4, and 8 cm H2O in six infants with tracheomalacia and five healthy control infants. In both groups of infants, FVC did not change with CPAP; however, inspiratory capacity (IC) decreased and thus FRC increased with increasing CPAP. FEFs at FRC increased with increasing levels of CPAP; however, the FEFs at 50% and 75% of expired volume were not different for the three levels of CPAP for both groups of infants. Our finding that FEFs measured at the same lung volumes did not differ for the different levels of CPAP indicates that CPAP affects forced flows primarily by increasing lung volume.

Original languageEnglish (US)
Pages (from-to)148-152
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume158
Issue number1
DOIs
StatePublished - Jan 1 1998

Fingerprint

Tracheomalacia
Continuous Positive Airway Pressure
Functional Residual Capacity
Lung
Inspiratory Capacity
Forced Expiratory Volume

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Effect of continuous positive airway pressure on forced expiratory flows in infants with tracheomalacia. / Davis, S.; Jones, M.; Kisling, J.; Angelicchio, C.; Tepper, R. S.

In: American journal of respiratory and critical care medicine, Vol. 158, No. 1, 01.01.1998, p. 148-152.

Research output: Contribution to journalArticle

@article{cad24a3a6fa948c783d52e9e41204476,
title = "Effect of continuous positive airway pressure on forced expiratory flows in infants with tracheomalacia",
abstract = "Continuous positive airway pressure (CPAP) is used to minimize airway collapse in infants with tracheomalacia. Forced expiratory flows (FEFs) at functional residual capacity (FRC) increase with increasing CPAP in infants with tracheomalacia, and it has been suggested that CPAP prevents airway collapse by 'stenting' the airway open. Since FEF is greater at higher than at lower lung volumes, we evaluated whether the increase in flow measured at FRC (V(FRC)) with CPAP could be explained by the increase in FRC with CPAP. We measured full FEF-volume curves at CPAP levels of 0, 4, and 8 cm H2O in six infants with tracheomalacia and five healthy control infants. In both groups of infants, FVC did not change with CPAP; however, inspiratory capacity (IC) decreased and thus FRC increased with increasing CPAP. FEFs at FRC increased with increasing levels of CPAP; however, the FEFs at 50{\%} and 75{\%} of expired volume were not different for the three levels of CPAP for both groups of infants. Our finding that FEFs measured at the same lung volumes did not differ for the different levels of CPAP indicates that CPAP affects forced flows primarily by increasing lung volume.",
author = "S. Davis and M. Jones and J. Kisling and C. Angelicchio and Tepper, {R. S.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1164/ajrccm.158.1.9711034",
language = "English (US)",
volume = "158",
pages = "148--152",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "1",

}

TY - JOUR

T1 - Effect of continuous positive airway pressure on forced expiratory flows in infants with tracheomalacia

AU - Davis, S.

AU - Jones, M.

AU - Kisling, J.

AU - Angelicchio, C.

AU - Tepper, R. S.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Continuous positive airway pressure (CPAP) is used to minimize airway collapse in infants with tracheomalacia. Forced expiratory flows (FEFs) at functional residual capacity (FRC) increase with increasing CPAP in infants with tracheomalacia, and it has been suggested that CPAP prevents airway collapse by 'stenting' the airway open. Since FEF is greater at higher than at lower lung volumes, we evaluated whether the increase in flow measured at FRC (V(FRC)) with CPAP could be explained by the increase in FRC with CPAP. We measured full FEF-volume curves at CPAP levels of 0, 4, and 8 cm H2O in six infants with tracheomalacia and five healthy control infants. In both groups of infants, FVC did not change with CPAP; however, inspiratory capacity (IC) decreased and thus FRC increased with increasing CPAP. FEFs at FRC increased with increasing levels of CPAP; however, the FEFs at 50% and 75% of expired volume were not different for the three levels of CPAP for both groups of infants. Our finding that FEFs measured at the same lung volumes did not differ for the different levels of CPAP indicates that CPAP affects forced flows primarily by increasing lung volume.

AB - Continuous positive airway pressure (CPAP) is used to minimize airway collapse in infants with tracheomalacia. Forced expiratory flows (FEFs) at functional residual capacity (FRC) increase with increasing CPAP in infants with tracheomalacia, and it has been suggested that CPAP prevents airway collapse by 'stenting' the airway open. Since FEF is greater at higher than at lower lung volumes, we evaluated whether the increase in flow measured at FRC (V(FRC)) with CPAP could be explained by the increase in FRC with CPAP. We measured full FEF-volume curves at CPAP levels of 0, 4, and 8 cm H2O in six infants with tracheomalacia and five healthy control infants. In both groups of infants, FVC did not change with CPAP; however, inspiratory capacity (IC) decreased and thus FRC increased with increasing CPAP. FEFs at FRC increased with increasing levels of CPAP; however, the FEFs at 50% and 75% of expired volume were not different for the three levels of CPAP for both groups of infants. Our finding that FEFs measured at the same lung volumes did not differ for the different levels of CPAP indicates that CPAP affects forced flows primarily by increasing lung volume.

UR - http://www.scopus.com/inward/record.url?scp=0031844272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031844272&partnerID=8YFLogxK

U2 - 10.1164/ajrccm.158.1.9711034

DO - 10.1164/ajrccm.158.1.9711034

M3 - Article

C2 - 9655721

AN - SCOPUS:0031844272

VL - 158

SP - 148

EP - 152

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 1

ER -