Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model

Christopher A. Murphy, Taranpreet Chandhoke, Zana Kalajzic, Rita Flynn, Achint Utreja, Sunil Wadhwa, Ravindra Nanda, Flavio Uribe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Introduction The aims of this study were to evaluate the effect of 2 distinct magnitudes of applied force with and without corticision (flapless corticotomy) on the rate of tooth movement and to examine the alveolar response in a rat model. Methods A total of 44 male rats (6 weeks old) were equally divided into 4 experimental groups based on force level and surgical intervention: light force, light force with corticision, heavy force, and heavy force with corticision. The forces were delivered from the maxillary left first molar to the maxillary incisors using prefabricated 10-g (light force) or 100-g (heavy force) nickel-titanium springs. The corticision procedure was performed at appliance placement and repeated 1 week later on the mesiopalatal aspect of the maxillary left first molars, with the right sides serving as the untreated controls. Microcomputed tomography was used to evaluate tooth movement between the maxillary first and second molars, and the alveolar response in the region of the maxillary first molar on day 14. Osteoclasts and odontoclasts were quantified, and the expression of receptor activator of nuclear factor kappa ß ligand was examined. Results Intragroup comparisons of bone volume fraction (BVF) and tissue density were found to be significantly less on the loaded sides, with the exception of BVF in the light force group. Intergroup comparisons evaluating magnitude of tooth movement, BVF, apparent density, and tissue density showed no significant differences. Histomorphometric analysis indicated that BVF was decreased in the light force group. No significant differences in the total numbers of osteoclasts and odontoclasts and the expression of receptor activator of nuclear factor kappa ß ligand were found between the groups. Conclusions No differences in tooth movement or alveolar response were observed with microcomputed tomography based on force level or corticision procedure. A flapless surgical insult in the mesiopalatal aspect of the first molar with a single-site corticision was unable to induce clinical or histologic changes after 2 weeks of orthodontic tooth movement regardless of the force magnitude. Histologic analysis of the furcation area showed that light force significantly decreased BVF.

Original languageEnglish (US)
Pages (from-to)55-66
Number of pages12
JournalAmerican Journal of Orthodontics and Dentofacial Orthopedics
Volume146
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Tooth Movement Techniques
Osteoclasts
Light
Bone and Bones
X-Ray Microtomography
Cytoplasmic and Nuclear Receptors
Ligands
Incisor

ASJC Scopus subject areas

  • Orthodontics

Cite this

Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model. / Murphy, Christopher A.; Chandhoke, Taranpreet; Kalajzic, Zana; Flynn, Rita; Utreja, Achint; Wadhwa, Sunil; Nanda, Ravindra; Uribe, Flavio.

In: American Journal of Orthodontics and Dentofacial Orthopedics, Vol. 146, No. 1, 2014, p. 55-66.

Research output: Contribution to journalArticle

Murphy, Christopher A. ; Chandhoke, Taranpreet ; Kalajzic, Zana ; Flynn, Rita ; Utreja, Achint ; Wadhwa, Sunil ; Nanda, Ravindra ; Uribe, Flavio. / Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model. In: American Journal of Orthodontics and Dentofacial Orthopedics. 2014 ; Vol. 146, No. 1. pp. 55-66.
@article{8aba05c2d35841858e40a01941dfd83d,
title = "Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model",
abstract = "Introduction The aims of this study were to evaluate the effect of 2 distinct magnitudes of applied force with and without corticision (flapless corticotomy) on the rate of tooth movement and to examine the alveolar response in a rat model. Methods A total of 44 male rats (6 weeks old) were equally divided into 4 experimental groups based on force level and surgical intervention: light force, light force with corticision, heavy force, and heavy force with corticision. The forces were delivered from the maxillary left first molar to the maxillary incisors using prefabricated 10-g (light force) or 100-g (heavy force) nickel-titanium springs. The corticision procedure was performed at appliance placement and repeated 1 week later on the mesiopalatal aspect of the maxillary left first molars, with the right sides serving as the untreated controls. Microcomputed tomography was used to evaluate tooth movement between the maxillary first and second molars, and the alveolar response in the region of the maxillary first molar on day 14. Osteoclasts and odontoclasts were quantified, and the expression of receptor activator of nuclear factor kappa {\ss} ligand was examined. Results Intragroup comparisons of bone volume fraction (BVF) and tissue density were found to be significantly less on the loaded sides, with the exception of BVF in the light force group. Intergroup comparisons evaluating magnitude of tooth movement, BVF, apparent density, and tissue density showed no significant differences. Histomorphometric analysis indicated that BVF was decreased in the light force group. No significant differences in the total numbers of osteoclasts and odontoclasts and the expression of receptor activator of nuclear factor kappa {\ss} ligand were found between the groups. Conclusions No differences in tooth movement or alveolar response were observed with microcomputed tomography based on force level or corticision procedure. A flapless surgical insult in the mesiopalatal aspect of the first molar with a single-site corticision was unable to induce clinical or histologic changes after 2 weeks of orthodontic tooth movement regardless of the force magnitude. Histologic analysis of the furcation area showed that light force significantly decreased BVF.",
author = "Murphy, {Christopher A.} and Taranpreet Chandhoke and Zana Kalajzic and Rita Flynn and Achint Utreja and Sunil Wadhwa and Ravindra Nanda and Flavio Uribe",
year = "2014",
doi = "10.1016/j.ajodo.2014.03.024",
language = "English (US)",
volume = "146",
pages = "55--66",
journal = "American Journal of Orthodontics and Dentofacial Orthopedics",
issn = "0889-5406",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model

AU - Murphy, Christopher A.

AU - Chandhoke, Taranpreet

AU - Kalajzic, Zana

AU - Flynn, Rita

AU - Utreja, Achint

AU - Wadhwa, Sunil

AU - Nanda, Ravindra

AU - Uribe, Flavio

PY - 2014

Y1 - 2014

N2 - Introduction The aims of this study were to evaluate the effect of 2 distinct magnitudes of applied force with and without corticision (flapless corticotomy) on the rate of tooth movement and to examine the alveolar response in a rat model. Methods A total of 44 male rats (6 weeks old) were equally divided into 4 experimental groups based on force level and surgical intervention: light force, light force with corticision, heavy force, and heavy force with corticision. The forces were delivered from the maxillary left first molar to the maxillary incisors using prefabricated 10-g (light force) or 100-g (heavy force) nickel-titanium springs. The corticision procedure was performed at appliance placement and repeated 1 week later on the mesiopalatal aspect of the maxillary left first molars, with the right sides serving as the untreated controls. Microcomputed tomography was used to evaluate tooth movement between the maxillary first and second molars, and the alveolar response in the region of the maxillary first molar on day 14. Osteoclasts and odontoclasts were quantified, and the expression of receptor activator of nuclear factor kappa ß ligand was examined. Results Intragroup comparisons of bone volume fraction (BVF) and tissue density were found to be significantly less on the loaded sides, with the exception of BVF in the light force group. Intergroup comparisons evaluating magnitude of tooth movement, BVF, apparent density, and tissue density showed no significant differences. Histomorphometric analysis indicated that BVF was decreased in the light force group. No significant differences in the total numbers of osteoclasts and odontoclasts and the expression of receptor activator of nuclear factor kappa ß ligand were found between the groups. Conclusions No differences in tooth movement or alveolar response were observed with microcomputed tomography based on force level or corticision procedure. A flapless surgical insult in the mesiopalatal aspect of the first molar with a single-site corticision was unable to induce clinical or histologic changes after 2 weeks of orthodontic tooth movement regardless of the force magnitude. Histologic analysis of the furcation area showed that light force significantly decreased BVF.

AB - Introduction The aims of this study were to evaluate the effect of 2 distinct magnitudes of applied force with and without corticision (flapless corticotomy) on the rate of tooth movement and to examine the alveolar response in a rat model. Methods A total of 44 male rats (6 weeks old) were equally divided into 4 experimental groups based on force level and surgical intervention: light force, light force with corticision, heavy force, and heavy force with corticision. The forces were delivered from the maxillary left first molar to the maxillary incisors using prefabricated 10-g (light force) or 100-g (heavy force) nickel-titanium springs. The corticision procedure was performed at appliance placement and repeated 1 week later on the mesiopalatal aspect of the maxillary left first molars, with the right sides serving as the untreated controls. Microcomputed tomography was used to evaluate tooth movement between the maxillary first and second molars, and the alveolar response in the region of the maxillary first molar on day 14. Osteoclasts and odontoclasts were quantified, and the expression of receptor activator of nuclear factor kappa ß ligand was examined. Results Intragroup comparisons of bone volume fraction (BVF) and tissue density were found to be significantly less on the loaded sides, with the exception of BVF in the light force group. Intergroup comparisons evaluating magnitude of tooth movement, BVF, apparent density, and tissue density showed no significant differences. Histomorphometric analysis indicated that BVF was decreased in the light force group. No significant differences in the total numbers of osteoclasts and odontoclasts and the expression of receptor activator of nuclear factor kappa ß ligand were found between the groups. Conclusions No differences in tooth movement or alveolar response were observed with microcomputed tomography based on force level or corticision procedure. A flapless surgical insult in the mesiopalatal aspect of the first molar with a single-site corticision was unable to induce clinical or histologic changes after 2 weeks of orthodontic tooth movement regardless of the force magnitude. Histologic analysis of the furcation area showed that light force significantly decreased BVF.

UR - http://www.scopus.com/inward/record.url?scp=84903631618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903631618&partnerID=8YFLogxK

U2 - 10.1016/j.ajodo.2014.03.024

DO - 10.1016/j.ajodo.2014.03.024

M3 - Article

C2 - 24974999

AN - SCOPUS:84903631618

VL - 146

SP - 55

EP - 66

JO - American Journal of Orthodontics and Dentofacial Orthopedics

JF - American Journal of Orthodontics and Dentofacial Orthopedics

SN - 0889-5406

IS - 1

ER -