Effect of crosslinking density on swelling and mechanical properties of PEGDA400/PCLTMA900 hydrogels

Jeremy Metz, Krista Gonnerman, Andy Chu, T.M. Gabriel Chu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A biodegradable polymer network hydrogel was fabricated and characterized for neural tissue engineering purposes. The proposed hydrogel contains both hydrophobic and hydrophilic components. The hydrophobic component is a three-arm poly(e-caprolactone) maleic acid with molecular weight of 900 (PCLTMA), and the hydrophilic component is poly(ethylene glycol) diacrylate macromer (PEGDA) with molecular weight of 400. A monolithic hard gel was generated by chemical photo-crosslinking. Three different networks, with varied ratios of PEGDA to PCLTMA including 25/75, 50/50 and 75/25, were characterized by compression testing, and the swelling properties were studied in phosphate-buffered saline (PBS, 7.4). The results of this study show that a wide-range of swelling data was obtained when the composition of PEGDA to PCLTMA was changed. The compressive modulus was measured for each composition, and the 75/25 gel was stiffer than the other compositions. These basic material properties will provide preliminary data for hydrogel development to be conducted in our laboratory.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalBiomedical Sciences Instrumentation
Volume42
StatePublished - Apr 2006

Fingerprint

Hydrogels
Crosslinking
Swelling
Hydrogel
Mechanical properties
Gels
Chemical analysis
Molecular weight
Compression testing
Biodegradable polymers
Molecular Weight
Tissue engineering
Polyethylene glycols
Materials properties
Phosphates
Tissue Engineering
Polymers
Acids
poly(ethylene glycol)diacrylate

Keywords

  • Hydrogel
  • Poly(ethylene glycol) diacrylate macromer
  • Three-arm poly(e-caprolactone) maleic acid

ASJC Scopus subject areas

  • Hardware and Architecture

Cite this

Effect of crosslinking density on swelling and mechanical properties of PEGDA400/PCLTMA900 hydrogels. / Metz, Jeremy; Gonnerman, Krista; Chu, Andy; Chu, T.M. Gabriel.

In: Biomedical Sciences Instrumentation, Vol. 42, 04.2006, p. 389-394.

Research output: Contribution to journalArticle

@article{913aaf2eeb6a45ea9a7e836027fad2d9,
title = "Effect of crosslinking density on swelling and mechanical properties of PEGDA400/PCLTMA900 hydrogels",
abstract = "A biodegradable polymer network hydrogel was fabricated and characterized for neural tissue engineering purposes. The proposed hydrogel contains both hydrophobic and hydrophilic components. The hydrophobic component is a three-arm poly(e-caprolactone) maleic acid with molecular weight of 900 (PCLTMA), and the hydrophilic component is poly(ethylene glycol) diacrylate macromer (PEGDA) with molecular weight of 400. A monolithic hard gel was generated by chemical photo-crosslinking. Three different networks, with varied ratios of PEGDA to PCLTMA including 25/75, 50/50 and 75/25, were characterized by compression testing, and the swelling properties were studied in phosphate-buffered saline (PBS, 7.4). The results of this study show that a wide-range of swelling data was obtained when the composition of PEGDA to PCLTMA was changed. The compressive modulus was measured for each composition, and the 75/25 gel was stiffer than the other compositions. These basic material properties will provide preliminary data for hydrogel development to be conducted in our laboratory.",
keywords = "Hydrogel, Poly(ethylene glycol) diacrylate macromer, Three-arm poly(e-caprolactone) maleic acid",
author = "Jeremy Metz and Krista Gonnerman and Andy Chu and Chu, {T.M. Gabriel}",
year = "2006",
month = "4",
language = "English",
volume = "42",
pages = "389--394",
journal = "Biomedical Sciences Instrumentation",
issn = "0067-8856",
publisher = "ISA - Instrumentation, Systems, and Automation Society",

}

TY - JOUR

T1 - Effect of crosslinking density on swelling and mechanical properties of PEGDA400/PCLTMA900 hydrogels

AU - Metz, Jeremy

AU - Gonnerman, Krista

AU - Chu, Andy

AU - Chu, T.M. Gabriel

PY - 2006/4

Y1 - 2006/4

N2 - A biodegradable polymer network hydrogel was fabricated and characterized for neural tissue engineering purposes. The proposed hydrogel contains both hydrophobic and hydrophilic components. The hydrophobic component is a three-arm poly(e-caprolactone) maleic acid with molecular weight of 900 (PCLTMA), and the hydrophilic component is poly(ethylene glycol) diacrylate macromer (PEGDA) with molecular weight of 400. A monolithic hard gel was generated by chemical photo-crosslinking. Three different networks, with varied ratios of PEGDA to PCLTMA including 25/75, 50/50 and 75/25, were characterized by compression testing, and the swelling properties were studied in phosphate-buffered saline (PBS, 7.4). The results of this study show that a wide-range of swelling data was obtained when the composition of PEGDA to PCLTMA was changed. The compressive modulus was measured for each composition, and the 75/25 gel was stiffer than the other compositions. These basic material properties will provide preliminary data for hydrogel development to be conducted in our laboratory.

AB - A biodegradable polymer network hydrogel was fabricated and characterized for neural tissue engineering purposes. The proposed hydrogel contains both hydrophobic and hydrophilic components. The hydrophobic component is a three-arm poly(e-caprolactone) maleic acid with molecular weight of 900 (PCLTMA), and the hydrophilic component is poly(ethylene glycol) diacrylate macromer (PEGDA) with molecular weight of 400. A monolithic hard gel was generated by chemical photo-crosslinking. Three different networks, with varied ratios of PEGDA to PCLTMA including 25/75, 50/50 and 75/25, were characterized by compression testing, and the swelling properties were studied in phosphate-buffered saline (PBS, 7.4). The results of this study show that a wide-range of swelling data was obtained when the composition of PEGDA to PCLTMA was changed. The compressive modulus was measured for each composition, and the 75/25 gel was stiffer than the other compositions. These basic material properties will provide preliminary data for hydrogel development to be conducted in our laboratory.

KW - Hydrogel

KW - Poly(ethylene glycol) diacrylate macromer

KW - Three-arm poly(e-caprolactone) maleic acid

UR - http://www.scopus.com/inward/record.url?scp=33745212897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745212897&partnerID=8YFLogxK

M3 - Article

C2 - 16817639

AN - SCOPUS:33745212897

VL - 42

SP - 389

EP - 394

JO - Biomedical Sciences Instrumentation

JF - Biomedical Sciences Instrumentation

SN - 0067-8856

ER -