Effect of Denervation on the Afferent Arteriole in the SHR

Vincent H. Gattone, Michael Shattuck, Friedrich C. Luft, J. Marc Overhage, L. R. Willis, Andrew P. Evan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To study the role the renal nerves may play in the hypertension of the SHR, we conducted a morphometric study of the afferent arteriole of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) which were subjected to renal denervation (or sham-operation). Methacrylate casts were made of the renal vasculature after perfusion fixation with glu tar aldehyde. These vascular casts were then examined and measurements made with the scanning electron microscope (SEM). Afferent arterioles of the denervated SHR were dilated in comparison to the sham-operated SHR, but there was no difference between the afferent arteriolar diameters of the 2 groups of WKYs. However, the afferent arteriolar diameters of the SHR (either group) were smaller than those of the WKY. Renal denervation caused a reduction in systolic blood pressure compared to sham-operated in both strains of rat. We concluded that the dilation changes of afferent arterioles of denervated SHRs may be related to renal autoregulation resulting from the decreased blood pressure. However, the effect of the loss of sympathetic innervation of the arterioles cannot be ruled out.

Original languageEnglish (US)
Pages (from-to)745-753
Number of pages9
JournalJapanese Heart Journal
Volume25
Issue number5
DOIs
StatePublished - Jan 1 1984

Fingerprint

Arterioles
Denervation
Inbred SHR Rats
Kidney
Inbred WKY Rats
Blood Pressure
Tars
Methacrylates
Aldehydes
Blood Vessels
Dilatation
Homeostasis
Perfusion
Electrons
Hypertension

Keywords

  • Afferent arteriole
  • Renal denervation
  • SHR

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gattone, V. H., Shattuck, M., Luft, F. C., Overhage, J. M., Willis, L. R., & Evan, A. P. (1984). Effect of Denervation on the Afferent Arteriole in the SHR. Japanese Heart Journal, 25(5), 745-753. https://doi.org/10.1536/ihj.25.745

Effect of Denervation on the Afferent Arteriole in the SHR. / Gattone, Vincent H.; Shattuck, Michael; Luft, Friedrich C.; Overhage, J. Marc; Willis, L. R.; Evan, Andrew P.

In: Japanese Heart Journal, Vol. 25, No. 5, 01.01.1984, p. 745-753.

Research output: Contribution to journalArticle

Gattone, VH, Shattuck, M, Luft, FC, Overhage, JM, Willis, LR & Evan, AP 1984, 'Effect of Denervation on the Afferent Arteriole in the SHR', Japanese Heart Journal, vol. 25, no. 5, pp. 745-753. https://doi.org/10.1536/ihj.25.745
Gattone VH, Shattuck M, Luft FC, Overhage JM, Willis LR, Evan AP. Effect of Denervation on the Afferent Arteriole in the SHR. Japanese Heart Journal. 1984 Jan 1;25(5):745-753. https://doi.org/10.1536/ihj.25.745
Gattone, Vincent H. ; Shattuck, Michael ; Luft, Friedrich C. ; Overhage, J. Marc ; Willis, L. R. ; Evan, Andrew P. / Effect of Denervation on the Afferent Arteriole in the SHR. In: Japanese Heart Journal. 1984 ; Vol. 25, No. 5. pp. 745-753.
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