Effect of dialysate calcium concentration on bone disease in patients on hemodialysis

R. J. Regan, Munro Peacock, S. M. Rosen, P. J. Robinson, A. Horsman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Plasma biochemistry, bone radiology and morphometry were studied in a group of 20 patients receiving maintenance hemodialysis. The aim was to determine if increasing the dialysate calcium concentration would decrease plasma parathyroid hormone and improve the radiologic appearances of bone in patients without producing serious side effects. Dialysate calcium concentration was increased stepwise from 4.5 to 6.0 and then to 7.0 mg/100 ml. Mean predialysis plasma calcium concentration increased from 9.4 to 9.7 and then to 10.0 mg/100 ml and mean predialysis phosphate concentration increased from 5.3 to 5.6 mg/100 ml. Parathyroid hormone concentration was elevated in all patients but the mean concentration did not change significantly although in seven patients a decrease occurred. Six patients had radiologic signs of renal bone disease, two patients showed improvement and three patients developed bone disease during the study. The patients with radiologic bone disease had the highest parathyroid hormone concentrations and the majority were female. Morphometric bone measurements showed that bone loss during the study occurred mainly in the male patients. Soft tissue calcification continued to ap.ear during the study. Although the response of some patients to an increased dialysate calcium concentration was favorable, it was impossible to predict which type of patient would benefit from the use of a dialysate calcium concentration of 7.0 mg/100 ml

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalKidney International
Volume10
Issue number3
StatePublished - 1976
Externally publishedYes

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Bone Diseases
Dialysis Solutions
Renal Dialysis
Calcium
Parathyroid Hormone
Bone and Bones
Radiology
Biochemistry
Ear
Phosphates
Maintenance
Kidney

ASJC Scopus subject areas

  • Nephrology

Cite this

Regan, R. J., Peacock, M., Rosen, S. M., Robinson, P. J., & Horsman, A. (1976). Effect of dialysate calcium concentration on bone disease in patients on hemodialysis. Kidney International, 10(3), 246-255.

Effect of dialysate calcium concentration on bone disease in patients on hemodialysis. / Regan, R. J.; Peacock, Munro; Rosen, S. M.; Robinson, P. J.; Horsman, A.

In: Kidney International, Vol. 10, No. 3, 1976, p. 246-255.

Research output: Contribution to journalArticle

Regan, RJ, Peacock, M, Rosen, SM, Robinson, PJ & Horsman, A 1976, 'Effect of dialysate calcium concentration on bone disease in patients on hemodialysis', Kidney International, vol. 10, no. 3, pp. 246-255.
Regan, R. J. ; Peacock, Munro ; Rosen, S. M. ; Robinson, P. J. ; Horsman, A. / Effect of dialysate calcium concentration on bone disease in patients on hemodialysis. In: Kidney International. 1976 ; Vol. 10, No. 3. pp. 246-255.
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