Effect of electro-acupuncture and moxibustion on brain connectivity in patients with crohn’s disease: A resting-state fMRI study

Chunhui Bao, Di Wang, Peng Liu, Yin Shi, Xiaoming Jin, Luyi Wu, Xiaoqing Zeng, Jianye Zhang, Huirong Liu, Huangan Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Acupuncture and moxibustion have been shown to be effective in treating Crohn’s disease (CD), but their therapeutic mechanisms remain unclear. Here we compared brain responses to either electro-acupuncture or moxibustion treatment in CD patients experiencing remission. A total of 65 patients were randomly divided into an electroacupuncture group (n = 32) or a moxibustion group (n = 33), and treated for 12 weeks. Eighteen patients in the electro-acupuncture group and 20 patients in the moxibustion group underwent resting-state functional magnetic resonance imaging at baseline and after treatment. Seed-based analysis was used to compare the restingstate functional connectivity (rsFC) between bilateral hippocampus and other brain regions before and after the treatments, as well as between the two groups. The CD activity index (CDAI) and inflammatory bowel disease questionnaire (IBDQ) were used to evaluate disease severity and patient quality of life. Electro-acupuncture and moxibustion both significantly reduced CDAI values and increased IBDQ scores. In the electro-acupuncture group, the rsFC values between bilateral hippocampus and anterior middle cingulate cortex (MCC) and insula were significantly increased, and the changes were negatively correlated with the CDAI scores. In the moxibustion group, the rsFC values between bilateral hippocampus and precuneus as well as inferior parietal lobe (IPC) were significantly elevated, and the changes were negatively correlated with the CDAI scores. We conclude that the therapeutic effects of electro-acupuncture and moxibustion on CD may involve the differently modulating brain homeostatic afferent processing network and default mode network (DMN), respectively.

Original languageEnglish (US)
Article number559
JournalFrontiers in Human Neuroscience
Volume11
DOIs
StatePublished - Nov 17 2017

Fingerprint

Moxibustion
Acupuncture
Crohn Disease
Magnetic Resonance Imaging
Brain
Hippocampus
Parietal Lobe
Inflammatory Bowel Diseases
Electroacupuncture
Gyrus Cinguli
Therapeutic Uses
Therapeutics
Seeds
Quality of Life

Keywords

  • Acupuncture
  • Crohn’s disease
  • Fmri
  • Functional connectivity
  • Moxibustion

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Effect of electro-acupuncture and moxibustion on brain connectivity in patients with crohn’s disease : A resting-state fMRI study. / Bao, Chunhui; Wang, Di; Liu, Peng; Shi, Yin; Jin, Xiaoming; Wu, Luyi; Zeng, Xiaoqing; Zhang, Jianye; Liu, Huirong; Wu, Huangan.

In: Frontiers in Human Neuroscience, Vol. 11, 559, 17.11.2017.

Research output: Contribution to journalArticle

Bao, Chunhui ; Wang, Di ; Liu, Peng ; Shi, Yin ; Jin, Xiaoming ; Wu, Luyi ; Zeng, Xiaoqing ; Zhang, Jianye ; Liu, Huirong ; Wu, Huangan. / Effect of electro-acupuncture and moxibustion on brain connectivity in patients with crohn’s disease : A resting-state fMRI study. In: Frontiers in Human Neuroscience. 2017 ; Vol. 11.
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