Effect of gender on radiation-induced cataractogenesis

Mark A. Henderson, Shailaja Valluri, Colleen Desrosiers, Jennifer T. Lopez, Christopher N. Batuello, Andrea Caperell-Grant, Marc S. Mendonca, Eva Marie Powers, Robert M. Bigsby, Joseph R. Dynlacht

Research output: Contribution to journalArticle

19 Scopus citations


Radiation cataractogenesis is an important consideration for radiotherapy patients and for astronauts. Data in the literature suggest that gender and/or estrogen may play a role in the incidence of age-related cataracts. However, few data exist on the effect of gender on radiation-induced cataractogenesis. We compared the incidence and rate of progression of cataracts induced by ionizing radiation in male and female Sprague-Dawley rats. Male rats were implanted with either an empty silastic capsule or a capsule containing 17-β-estradiol. Ovary-intact female rats were implanted with empty capsules. All rats received a single dose of 10 Gy (60Co γ rays) to the right eye only. Lens opacification was measured at 24-week intervals with a slit lamp. The incidence of radiation-induced cataracts was significantly increased in male rats compared to female rats (P 0.034). There was no difference in the rate of cataract progression between the three groups. Our data suggest there is a gender-related difference in radiation-induced cataractogenesis, but the increased incidence of radiation cataractogenesis in male rats compared to female rats cannot be attributed to estrogen levels, since there was no difference in cataract incidence between male rats implanted with empty capsules and those implanted with capsules containing 17-β-estradiol.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalRadiation research
Issue number1
StatePublished - Jul 1 2009

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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    Henderson, M. A., Valluri, S., Desrosiers, C., Lopez, J. T., Batuello, C. N., Caperell-Grant, A., Mendonca, M. S., Powers, E. M., Bigsby, R. M., & Dynlacht, J. R. (2009). Effect of gender on radiation-induced cataractogenesis. Radiation research, 172(1), 129-133. https://doi.org/10.1667/RR1589.1