Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats

Sherry Queener, F. C. Luft, F. G. Hamel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume24
Issue number5
StatePublished - 1983

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Gentamicins
Adenylyl Cyclases
Kidney
Cell Membrane
Isoproterenol
Phospholipids
Nucleotides
Pharmaceutical Preparations
sodium-translocating ATPase

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats. / Queener, Sherry; Luft, F. C.; Hamel, F. G.

In: Antimicrobial Agents and Chemotherapy, Vol. 24, No. 5, 1983, p. 815-818.

Research output: Contribution to journalArticle

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