The effect of glycine on urinary risk factors of kidney stone disease was investigated in 6 male stone formers and 6 normal males. The subjects were studied on a basal diet for one week. During the subsequent week, the same diet was supplemented with 53.3 mmol of glycine. The analysis of 24-hour urine samples collected during the last three days of each study period showed that urinary oxalate increased in three of the six stone formers and five of the six normal males on high glycine diet, however, the increase was non-significant. Five of six normal males also showed a significant (P<0.05) increase in urinary calcium and volume. There was no change in urinary pH or excretion of uric acid and alcian blue precipitable polyanions (ABPP) either in male stone formers or in normal males. Thus the overall probability of stone formation was not affected significantly.
- stone formation
- uric acid
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics