Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum

S. Khulusi, M. A. Mendall, Sunil Badve, P. Patel, C. Finlayson, T. C. Northfield

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Helicobacter pylori associated duodenal ulcers occur in patches of gastric metaplasia. The pathogenesis of gastric metaplasia is unclear, but it has been produced in experimental animals by acute injury and has been shown to be present to a greater extent of H pylori positive subjects. This study aimed to discover if gastric metaplasia regressed with eradication of H pylori or healing of duodenal ulcers, or both. Thirty two duodenal ulcer patients with H pylori infection confirmed by biopsy urease test and by antral histological examination were studied. Patients were treated with triple therapy (deNol 240 mg twice daily, amoxycillin 500 mg three times daily, and metronidazole 400 mg three times daily) for two weeks after the first endoscopy and were subsequently re-endoscoped. Three duodenal bulb biopsy specimens were obtained per patient at each endoscopy. Biopsy sections were stained with haematoxylin and eosin to determine the severity of duodenitis, and with diastase periodic acid-Schiff/alcian blue to assess the extent of gastric metaplasia. Slides were assessed by two histopathologists unaware of treatment status. H pylori was eradicated in 63% of subjects and all ulcers were healed at follow up. The median extent of gastric metaplasia at the start of treatment and 6-18 months (median 10) after treatment was compared in the two groups. Gastric metaplasia declined in eradicators from 16% to 8% (p

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalGut
Volume36
Issue number2
StatePublished - Feb 1995
Externally publishedYes

Fingerprint

Metaplasia
Duodenum
Helicobacter pylori
Stomach
Pylorus
Duodenal Ulcer
Biopsy
Endoscopy
Duodenitis
Alcian Blue
Periodic Acid
Urease
Amoxicillin
Metronidazole
Therapeutics
Hematoxylin
Amylases
Eosine Yellowish-(YS)
Ulcer
Wounds and Injuries

Keywords

  • Duodenum
  • Gastric metaplasia
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Khulusi, S., Mendall, M. A., Badve, S., Patel, P., Finlayson, C., & Northfield, T. C. (1995). Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. Gut, 36(2), 193-197.

Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. / Khulusi, S.; Mendall, M. A.; Badve, Sunil; Patel, P.; Finlayson, C.; Northfield, T. C.

In: Gut, Vol. 36, No. 2, 02.1995, p. 193-197.

Research output: Contribution to journalArticle

Khulusi, S, Mendall, MA, Badve, S, Patel, P, Finlayson, C & Northfield, TC 1995, 'Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum', Gut, vol. 36, no. 2, pp. 193-197.
Khulusi S, Mendall MA, Badve S, Patel P, Finlayson C, Northfield TC. Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. Gut. 1995 Feb;36(2):193-197.
Khulusi, S. ; Mendall, M. A. ; Badve, Sunil ; Patel, P. ; Finlayson, C. ; Northfield, T. C. / Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. In: Gut. 1995 ; Vol. 36, No. 2. pp. 193-197.
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