Effect of hesperidin with and without a calcium (calcilock) supplement on bone health in postmenopausal women

Berdine R. Martin, George P. McCabe, Linda McCabe, George S. Jackson, Marie Noelle Horcajada, Elizabeth Offord-Cavin, Munro Peacock, Connie M. Weaver

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Context: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. Objective: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. Design: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, 41Ca, from bone. Results: Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P <.04). Conclusion: Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)923-927
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number3
DOIs
StatePublished - Mar 2016

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Martin, B. R., McCabe, G. P., McCabe, L., Jackson, G. S., Horcajada, M. N., Offord-Cavin, E., Peacock, M., & Weaver, C. M. (2016). Effect of hesperidin with and without a calcium (calcilock) supplement on bone health in postmenopausal women. Journal of Clinical Endocrinology and Metabolism, 101(3), 923-927. https://doi.org/10.1210/jc.2015-3767