Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats

Eric Engleman, Cynthia M. Ingraham, Caryn E. O'Brien, William J. McBride, James M. Murphy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels was investigated in the nucleus accumbens (NAC) of P rats. Rats were double-housed (DH) in plastic tubs, or single-housed (SH) in hanging wire cages for 12 weeks. Microdialysis in the NAC showed greater sulpiride-induced DA increases in the NAC of SH vs. DH rats, with no difference in basal levels. The data indicate that housing conditions can alter DA D 2 receptor function in the NAC.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalBrain Research
Volume1022
Issue number1-2
DOIs
StatePublished - Oct 1 2004

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Sulpiride
Nucleus Accumbens
Dopamine
Alcohols
Microdialysis
Plastics

Keywords

  • D2 receptor
  • Environmental factor
  • In vivo microdialysis
  • Neuroadaptation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats. / Engleman, Eric; Ingraham, Cynthia M.; O'Brien, Caryn E.; McBride, William J.; Murphy, James M.

In: Brain Research, Vol. 1022, No. 1-2, 01.10.2004, p. 247-250.

Research output: Contribution to journalArticle

Engleman, Eric ; Ingraham, Cynthia M. ; O'Brien, Caryn E. ; McBride, William J. ; Murphy, James M. / Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats. In: Brain Research. 2004 ; Vol. 1022, No. 1-2. pp. 247-250.
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