Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats

Eric A. Engleman, Cynthia M. Ingraham, Caryn E. O'Brien, William J. McBride, James M. Murphy

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels was investigated in the nucleus accumbens (NAC) of P rats. Rats were double-housed (DH) in plastic tubs, or single-housed (SH) in hanging wire cages for 12 weeks. Microdialysis in the NAC showed greater sulpiride-induced DA increases in the NAC of SH vs. DH rats, with no difference in basal levels. The data indicate that housing conditions can alter DA D 2 receptor function in the NAC.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalBrain research
Volume1022
Issue number1-2
DOIs
StatePublished - Oct 1 2004

Keywords

  • D2 receptor
  • Environmental factor
  • In vivo microdialysis
  • Neuroadaptation

ASJC Scopus subject areas

  • Neuroscience(all)

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