Effect of inotropic stimulation on left atrial appendage function in atrial myopathy of chronic atrial fibrillation

Masoor Kamalesh, T. Burton Copeland, Stephen Sawada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Atrial fibrillation (AF) leads to remodeling of the left atrium (LA) and left atrial appendage (LAA), resulting in atrial myopathy. Reduced LA and LAA function in chronic AF leads to thrombus formation and spontaneous echo contrast (SEC). The effect of inotropic stimulation on LAA function in patients with chronic AF is unknown. LAA emptying velocity (LAAEV) and maximal LAA area at baseline and after dobutamine were measured by transesophageal echocardiography in 14 subjects in normal sinus rhythm (NSR) and 6 subjects in AF. SEC in the LA was assessed before and after dobutamine. LAAEV increased significantly in both groups. However, the LAAEV at peak dobutamine in patients with AF remained significantly lower than the baseline LAAEV in patients who were in NSR (P = 0.009). Maximal LAA area decreased significantly with dobutamine in both groups, but LAA area at peak dose of dobutamine in patients with AF remained greater than baseline area in those in NSR (P = 0.01). Despite the increase in LAAEV, SEC improved in only two of five patients. We conclude that during AF, the LAA responds to inotropic stimulation with only a modest improvement in function.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalEchocardiography
Volume17
Issue number4
StatePublished - 2000

Fingerprint

Left Atrial Function
Atrial Appendage
Muscular Diseases
Atrial Fibrillation
Dobutamine
Heart Atria
Transesophageal Echocardiography
Thrombosis

Keywords

  • Atrial appendage
  • Atrial fibrillation
  • Inotropy
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of inotropic stimulation on left atrial appendage function in atrial myopathy of chronic atrial fibrillation. / Kamalesh, Masoor; Burton Copeland, T.; Sawada, Stephen.

In: Echocardiography, Vol. 17, No. 4, 2000, p. 313-318.

Research output: Contribution to journalArticle

@article{58e371ec1eb64999a7379058dea9addf,
title = "Effect of inotropic stimulation on left atrial appendage function in atrial myopathy of chronic atrial fibrillation",
abstract = "Atrial fibrillation (AF) leads to remodeling of the left atrium (LA) and left atrial appendage (LAA), resulting in atrial myopathy. Reduced LA and LAA function in chronic AF leads to thrombus formation and spontaneous echo contrast (SEC). The effect of inotropic stimulation on LAA function in patients with chronic AF is unknown. LAA emptying velocity (LAAEV) and maximal LAA area at baseline and after dobutamine were measured by transesophageal echocardiography in 14 subjects in normal sinus rhythm (NSR) and 6 subjects in AF. SEC in the LA was assessed before and after dobutamine. LAAEV increased significantly in both groups. However, the LAAEV at peak dobutamine in patients with AF remained significantly lower than the baseline LAAEV in patients who were in NSR (P = 0.009). Maximal LAA area decreased significantly with dobutamine in both groups, but LAA area at peak dose of dobutamine in patients with AF remained greater than baseline area in those in NSR (P = 0.01). Despite the increase in LAAEV, SEC improved in only two of five patients. We conclude that during AF, the LAA responds to inotropic stimulation with only a modest improvement in function.",
keywords = "Atrial appendage, Atrial fibrillation, Inotropy, Thrombosis",
author = "Masoor Kamalesh and {Burton Copeland}, T. and Stephen Sawada",
year = "2000",
language = "English",
volume = "17",
pages = "313--318",
journal = "Echocardiography",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Effect of inotropic stimulation on left atrial appendage function in atrial myopathy of chronic atrial fibrillation

AU - Kamalesh, Masoor

AU - Burton Copeland, T.

AU - Sawada, Stephen

PY - 2000

Y1 - 2000

N2 - Atrial fibrillation (AF) leads to remodeling of the left atrium (LA) and left atrial appendage (LAA), resulting in atrial myopathy. Reduced LA and LAA function in chronic AF leads to thrombus formation and spontaneous echo contrast (SEC). The effect of inotropic stimulation on LAA function in patients with chronic AF is unknown. LAA emptying velocity (LAAEV) and maximal LAA area at baseline and after dobutamine were measured by transesophageal echocardiography in 14 subjects in normal sinus rhythm (NSR) and 6 subjects in AF. SEC in the LA was assessed before and after dobutamine. LAAEV increased significantly in both groups. However, the LAAEV at peak dobutamine in patients with AF remained significantly lower than the baseline LAAEV in patients who were in NSR (P = 0.009). Maximal LAA area decreased significantly with dobutamine in both groups, but LAA area at peak dose of dobutamine in patients with AF remained greater than baseline area in those in NSR (P = 0.01). Despite the increase in LAAEV, SEC improved in only two of five patients. We conclude that during AF, the LAA responds to inotropic stimulation with only a modest improvement in function.

AB - Atrial fibrillation (AF) leads to remodeling of the left atrium (LA) and left atrial appendage (LAA), resulting in atrial myopathy. Reduced LA and LAA function in chronic AF leads to thrombus formation and spontaneous echo contrast (SEC). The effect of inotropic stimulation on LAA function in patients with chronic AF is unknown. LAA emptying velocity (LAAEV) and maximal LAA area at baseline and after dobutamine were measured by transesophageal echocardiography in 14 subjects in normal sinus rhythm (NSR) and 6 subjects in AF. SEC in the LA was assessed before and after dobutamine. LAAEV increased significantly in both groups. However, the LAAEV at peak dobutamine in patients with AF remained significantly lower than the baseline LAAEV in patients who were in NSR (P = 0.009). Maximal LAA area decreased significantly with dobutamine in both groups, but LAA area at peak dose of dobutamine in patients with AF remained greater than baseline area in those in NSR (P = 0.01). Despite the increase in LAAEV, SEC improved in only two of five patients. We conclude that during AF, the LAA responds to inotropic stimulation with only a modest improvement in function.

KW - Atrial appendage

KW - Atrial fibrillation

KW - Inotropy

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=0034044480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034044480&partnerID=8YFLogxK

M3 - Article

C2 - 10978999

AN - SCOPUS:0034044480

VL - 17

SP - 313

EP - 318

JO - Echocardiography

JF - Echocardiography

SN - 0742-2822

IS - 4

ER -