Effect of Internal Adenine Nucleotides on Sodium Pump-Catalyzed Na-Na and Na-K Exchanges

Brian G. Kennedy, Gorm Lunn, Joseph F. Hoffman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This chapter discusses the effect of internal adenine nucleotides on sodium pump-catalyzed Na–Na and Na–K exchanges. Na–K exchange is a saturating function of internal ATP. An increase in the concentration of ADP and ATP held constant, there is a sharp decrease in Na–K exchange. The inhibition by ADP is dependent on the ATP concentration because the ADP effect diminishes with increasing ATP concentrations. On the other hand, Na–Na exchange depends on the concentration of ADP. However ADP activation is independent of the ATP concentration.

Original languageEnglish (US)
Pages (from-to)683-686
Number of pages4
JournalCurrent Topics in Membranes and Transport
Volume19
Issue numberC
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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