Effect of intraocular pressure on the hemodynamics of the central retinal artery: A mathematical model

Giovanna Guidoboni, Alon Harris, Lucia Carichino, Yoel Arieli, Brent A. Siesky

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Retinal hemodynamics plays a crucial role in the pathophysiology of several ocular diseases. There are clear evidences that the hemodynamics of the central retinal artery (CRA) is strongly affected by the level of intraocular pressure (IOP), which is the pressure inside the eye globe. However, the mechanisms through which this occurs are still elusive. The main goal of this paper is to develop a mathematical model that combines the mechanical action of IOP and the blood flow in the CRA to elucidate the mechanisms through which IOP elevation affects the CRA hemodynamics. Our model suggests that the development of radial compressive regions in the lamina cribrosa (a collagen structure in the optic nerve pierced by the CRA approximately in its center) might be responsible for the clinically-observed blood velocity reduction in the CRA following IOP elevation. The predictions of the mathematical model are in very good agreement with experimental and clinical data. Our model also identifies radius and thickness of the lamina cribrosa as major factors affecting the IOP-CRA relationship, suggesting that anatomical differences among individuals might lead to different hemodynamic responses to IOP elevation.

Original languageEnglish (US)
Pages (from-to)523-546
Number of pages24
JournalMathematical Biosciences and Engineering
Volume11
Issue number3
DOIs
StatePublished - Jun 1 2014

Fingerprint

Retinal Artery
Hemodynamics
Arteries
hemodynamics
Intraocular Pressure
arteries
Theoretical Models
mathematical models
Mathematical Model
Mathematical models
Lamina
laminae (animals)
Blood
Pathophysiology
Eye Diseases
eye diseases
Incentre
Globe
Optic Nerve
Individual Differences

Keywords

  • Central retinal artery
  • Fluid-structure interaction
  • Intraocular pressure
  • Lamina cribrosa
  • Ocular blood flow

ASJC Scopus subject areas

  • Applied Mathematics
  • Modeling and Simulation
  • Computational Mathematics
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

Effect of intraocular pressure on the hemodynamics of the central retinal artery : A mathematical model. / Guidoboni, Giovanna; Harris, Alon; Carichino, Lucia; Arieli, Yoel; Siesky, Brent A.

In: Mathematical Biosciences and Engineering, Vol. 11, No. 3, 01.06.2014, p. 523-546.

Research output: Contribution to journalArticle

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