Effect of lysophosphatidylcholine on renal hemodynamics and excretory function in anesthetized rats

Rajash Handa, Vardaman M. Buckalew

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of myristoyl-lysophosphatidylcholine (myristoyl-LPC) on renal hemodynamics, electrolyte and water excretion was examined over a 90 min period in sodium pentobarbital anesthetized male Sprague Dawley rats. Intravenous infusion of myristoyl-LPC at 13 ± 3 pmol/min resulted in a small fall in systemic blood pressure, a 13% decrease in renal plasma flow without significantly altering glomerular filtration rate and produced a slightly greater excretion of sodium and water than vehicle controls. These results suggest that short term myristoyl-LPC administration can significantly alter renal function producing a weak natriuresis and diuresis which is not dependent on systemic blood pressure and renal hemodynamic changes.

Original languageEnglish (US)
Pages (from-to)1571-1575
Number of pages5
JournalLife Sciences
Volume51
Issue number20
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Lysophosphatidylcholines
Hemodynamics
Rats
Blood pressure
Kidney
Blood Pressure
Renal Plasma Flow
Plasma flow
Natriuresis
Water
Diuresis
Pentobarbital
Glomerular Filtration Rate
Intravenous Infusions
Electrolytes
Sprague Dawley Rats
Sodium

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of lysophosphatidylcholine on renal hemodynamics and excretory function in anesthetized rats. / Handa, Rajash; Buckalew, Vardaman M.

In: Life Sciences, Vol. 51, No. 20, 1992, p. 1571-1575.

Research output: Contribution to journalArticle

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