Effect of maternal fasting on ovine fetal and maternal branched-chain amino acid transaminase activities

Edward A. Liechty, Suzanne Barone, Mitchell Nutt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Activities of branched-chain amino acid transaminase were assayed in maternal skeletal muscle, liver and fetal skeletal muscle, cardiac muscle, liver, kidney and placenta obtained from fed and 5-day-fasted late gestation ewes. Very high activities were found in placenta; fetal skeletal muscle also had high activity. Fetal brain had intermediate activity, followed by cardiac muscle and kidney. Fetal liver possessed negligible activity. Activities were low in both maternal liver and skeletal muscle. Trends were seen for fasting to increase activities in fetal placenta, skeletal muscle, brain, kidney, heart and maternal liver, but these changes were statistically significant only for fetal brain and placental tissue. Fetal skeletal muscle activity was 100 times that of maternal skeletal muscle. These data imply differences in the metabolism of the branched-chain amino acids by fetal and adult ruminants and expand the thesis that branched-chain amino acids are important to the metabolism of the ovine fetus.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalNeonatology
Volume52
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Fasting
Sheep
Skeletal Muscle
Mothers
Liver
Placenta
Branched Chain Amino Acids
Kidney
Myocardium
Brain
Fetal Movement
Ruminants
branched-chain-amino-acid transaminase
Fetus
Pregnancy

Keywords

  • Branched-chain amino acid transaminase
  • Ovine fetal metabolism
  • Pregnant ewes

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of maternal fasting on ovine fetal and maternal branched-chain amino acid transaminase activities. / Liechty, Edward A.; Barone, Suzanne; Nutt, Mitchell.

In: Neonatology, Vol. 52, No. 3, 1987, p. 166-173.

Research output: Contribution to journalArticle

Liechty, Edward A. ; Barone, Suzanne ; Nutt, Mitchell. / Effect of maternal fasting on ovine fetal and maternal branched-chain amino acid transaminase activities. In: Neonatology. 1987 ; Vol. 52, No. 3. pp. 166-173.
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