Abstract
Beta-funaltrexamine (beta-FNA), a selective mu opioid receptor antagonist, when administered in doses of 10.0, 15.0, and 20.0 mg/kg b.wt., decreased alcohol but not water intake in a dose-dependent manner in rats selectively bred for high alcohol intake (HAD line) Beta-FNA also suppressed the intake of a saccharin solution containing alcohol without altering the intake of a similar solution without alcohol. The results suggest that beta- FNA may prove useful as a pharmacotherapeutic agent for the treatment of alcohol dependence. In a second study, pituitary beta-endorphin gene expression (proopiomelanocortin or POMC messinger ribonucleic acid - mRNA) was compared in another pair of rat lines selectively bred for high or low alcohol intake (alcohol-preferring or P and alcohol-nonpreferring or NP lines). A repeated alcohol challenge (1.0 g/kg b.wt./day, IP for 4 days) produced a greater increase in POMC mRNA in the anterior and neurointermediate lobes of the pituitary of P rats compared with NP rats. The results suggest that a genetic predisposition toward high alcohol drinking may be associated with increased responsiveness of the opioid system to alcohol.
| Original language | English |
|---|---|
| Pages (from-to) | 627-635 |
| Number of pages | 9 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1998 |
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Keywords
- Alcohol drinking
- Alcohol preference
- Beta-FNA
- Genetic selection
- mRNA
- Opioid antagonists
- Opioid receptors
- Pituitary gland
- Rats
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Effect of Mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. / Krishnan-Sarin, S.; Wand, G. S.; Li, X. W.; Portoghese, P. S.; Froehlich, Janice.
In: Pharmacology Biochemistry and Behavior, Vol. 59, No. 3, 03.1998, p. 627-635.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking
AU - Krishnan-Sarin, S.
AU - Wand, G. S.
AU - Li, X. W.
AU - Portoghese, P. S.
AU - Froehlich, Janice
PY - 1998/3
Y1 - 1998/3
N2 - Beta-funaltrexamine (beta-FNA), a selective mu opioid receptor antagonist, when administered in doses of 10.0, 15.0, and 20.0 mg/kg b.wt., decreased alcohol but not water intake in a dose-dependent manner in rats selectively bred for high alcohol intake (HAD line) Beta-FNA also suppressed the intake of a saccharin solution containing alcohol without altering the intake of a similar solution without alcohol. The results suggest that beta- FNA may prove useful as a pharmacotherapeutic agent for the treatment of alcohol dependence. In a second study, pituitary beta-endorphin gene expression (proopiomelanocortin or POMC messinger ribonucleic acid - mRNA) was compared in another pair of rat lines selectively bred for high or low alcohol intake (alcohol-preferring or P and alcohol-nonpreferring or NP lines). A repeated alcohol challenge (1.0 g/kg b.wt./day, IP for 4 days) produced a greater increase in POMC mRNA in the anterior and neurointermediate lobes of the pituitary of P rats compared with NP rats. The results suggest that a genetic predisposition toward high alcohol drinking may be associated with increased responsiveness of the opioid system to alcohol.
AB - Beta-funaltrexamine (beta-FNA), a selective mu opioid receptor antagonist, when administered in doses of 10.0, 15.0, and 20.0 mg/kg b.wt., decreased alcohol but not water intake in a dose-dependent manner in rats selectively bred for high alcohol intake (HAD line) Beta-FNA also suppressed the intake of a saccharin solution containing alcohol without altering the intake of a similar solution without alcohol. The results suggest that beta- FNA may prove useful as a pharmacotherapeutic agent for the treatment of alcohol dependence. In a second study, pituitary beta-endorphin gene expression (proopiomelanocortin or POMC messinger ribonucleic acid - mRNA) was compared in another pair of rat lines selectively bred for high or low alcohol intake (alcohol-preferring or P and alcohol-nonpreferring or NP lines). A repeated alcohol challenge (1.0 g/kg b.wt./day, IP for 4 days) produced a greater increase in POMC mRNA in the anterior and neurointermediate lobes of the pituitary of P rats compared with NP rats. The results suggest that a genetic predisposition toward high alcohol drinking may be associated with increased responsiveness of the opioid system to alcohol.
KW - Alcohol drinking
KW - Alcohol preference
KW - Beta-FNA
KW - Genetic selection
KW - mRNA
KW - Opioid antagonists
KW - Opioid receptors
KW - Pituitary gland
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=0032030917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032030917&partnerID=8YFLogxK
U2 - 10.1016/S0091-3057(97)00474-7
DO - 10.1016/S0091-3057(97)00474-7
M3 - Article
VL - 59
SP - 627
EP - 635
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -