Effect of neuromuscular blockade on fetal oxidative metabolism

R. B. Wilkening, David Boyle

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Because fetal neuromuscular blockade has been used during cord blood sampling procedures to prevent fetal movement, we studied the effect of pancuronium bromide on fetal arterial concentrations of glucose, lactate, and oxygen and their umbilical uptake in 6 chronically prepared fetal sheep. We observed a significant increase in the arterial concentrations and decrease in the umbilical uptakes. We suggest that cord blood sampling procedures for fetal assessment of oxidative metabolism not be performed after fetal neuromuscular blockade so that data obtained might best reflect the unperturbed physiological condition of the fetus.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalBiology of the Neonate
Volume58
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Cordocentesis
Umbilicus
Neuromuscular Blockade
Pancuronium
Fetal Movement
Lactic Acid
Sheep
Fetus
Oxygen
Glucose

Keywords

  • fetal sheep
  • oxygen uptake
  • pancuronium bromide
  • umbilical glucose uptake
  • umbilical lactate uptake

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of neuromuscular blockade on fetal oxidative metabolism. / Wilkening, R. B.; Boyle, David.

In: Biology of the Neonate, Vol. 58, No. 1, 1990, p. 57-60.

Research output: Contribution to journalArticle

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