Effect of Octreotide on Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation

Kalyan Ray Parashette, Shamaila Waseem, Debra Horn, Aali Shah, Joseph Croffie

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03±1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32±1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89±1.37 (95% CI 6.14-7.64) and 6.71±1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73±1.32 (95% CI 7.01-8.45) and 7.53±1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.

Original languageEnglish (US)
Pages (from-to)626-629
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume61
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Octreotide
Constipation
Confidence Intervals
Pediatrics
Encopresis
Manometry
Prospective Studies

Keywords

  • colonic dysmotility
  • colonic manometry
  • constipation
  • Motility Index
  • octreotide

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of Octreotide on Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation. / Ray Parashette, Kalyan; Waseem, Shamaila; Horn, Debra; Shah, Aali; Croffie, Joseph.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 61, No. 6, 01.12.2015, p. 626-629.

Research output: Contribution to journalArticle

Ray Parashette, Kalyan ; Waseem, Shamaila ; Horn, Debra ; Shah, Aali ; Croffie, Joseph. / Effect of Octreotide on Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation. In: Journal of Pediatric Gastroenterology and Nutrition. 2015 ; Vol. 61, No. 6. pp. 626-629.
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title = "Effect of Octreotide on Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation",
abstract = "Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84{\%}) had normal colonic manometry and 2 patients (16{\%}) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03±1.26 (95{\%} confidence interval [CI] 5.35-6.72) and 5.32±1.66 (95{\%} CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89±1.37 (95{\%} CI 6.14-7.64) and 6.71±1.47 (95{\%} CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73±1.32 (95{\%} CI 7.01-8.45) and 7.53±1.38 (95{\%} CI 6.78-8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.",
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AU - Waseem, Shamaila

AU - Horn, Debra

AU - Shah, Aali

AU - Croffie, Joseph

PY - 2015/12/1

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N2 - Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03±1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32±1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89±1.37 (95% CI 6.14-7.64) and 6.71±1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73±1.32 (95% CI 7.01-8.45) and 7.53±1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.

AB - Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03±1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32±1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89±1.37 (95% CI 6.14-7.64) and 6.71±1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73±1.32 (95% CI 7.01-8.45) and 7.53±1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.

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