Effect of Octreotide on Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation

Kalyan Ray Parashette, Shamaila Waseem, Debra Horn, Aali Shah, Joseph Croffie

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03±1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32±1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89±1.37 (95% CI 6.14-7.64) and 6.71±1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73±1.32 (95% CI 7.01-8.45) and 7.53±1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.

Original languageEnglish (US)
Pages (from-to)626-629
Number of pages4
JournalJournal of pediatric gastroenterology and nutrition
Volume61
Issue number6
DOIs
StatePublished - Dec 1 2015

Keywords

  • Motility Index
  • colonic dysmotility
  • colonic manometry
  • constipation
  • octreotide

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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