Abstract
Cavitation appears to contribute to tissue injury in lithotripsy. Reports have shown that increasing pulse repetition frequency [(PRF) 0.5-100 Hz] increases tissue damage and increasing static pressure (1-3 bar) reduces cell damage without decreasing stone comminution. Our hypothesis is that overpressure or slow PRF causes unstabilized bubbles produced by one shock pulse to dissolve before they nucleate cavitation by subsequent shock pulses. The effects of PRF and overpressure on bubble dynamics and lifetimes were studied experimentally with passive cavitation detection, high-speed photography, and B-mode ultrasound and theoretically. Overpressure significantly reduced calculated (100-2 s) and measured (55-0.5 s) bubble lifetimes. At 1.5 bar static pressure, a dense bubble cluster was measured with clinically high PRF (2-3 Hz) and a sparse cluster with clinically low PRF (0.5-1 Hz), indicating bubble lifetimes of 0.5-1 s, consistent with calculations. In contrast to cavitation in water, high-speed photography showed that overpressure did not suppress cavitation of bubbles stabilized on a cracked surface. These results suggest that a judicious use of overpressure and PRF in lithotripsy could reduce cavitation damage of tissue while maintaining cavitation comminution of stones.
| Original language | English |
|---|---|
| Pages (from-to) | 1183-1195 |
| Number of pages | 13 |
| Journal | Journal of the Acoustical Society of America |
| Volume | 112 |
| Issue number | 3 I |
| DOIs | |
| State | Published - Sep 2002 |
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ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Effect of overpressure and pulse repetition frequency on cavitation in shock wave lithotripsy. / Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Bailey, Michael R.; Williams, James; McAteer, James A.; Cleveland, Robin O.; Crum, Lawrence A.
In: Journal of the Acoustical Society of America, Vol. 112, No. 3 I, 09.2002, p. 1183-1195.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of overpressure and pulse repetition frequency on cavitation in shock wave lithotripsy
AU - Sapozhnikov, Oleg A.
AU - Khokhlova, Vera A.
AU - Bailey, Michael R.
AU - Williams, James
AU - McAteer, James A.
AU - Cleveland, Robin O.
AU - Crum, Lawrence A.
PY - 2002/9
Y1 - 2002/9
N2 - Cavitation appears to contribute to tissue injury in lithotripsy. Reports have shown that increasing pulse repetition frequency [(PRF) 0.5-100 Hz] increases tissue damage and increasing static pressure (1-3 bar) reduces cell damage without decreasing stone comminution. Our hypothesis is that overpressure or slow PRF causes unstabilized bubbles produced by one shock pulse to dissolve before they nucleate cavitation by subsequent shock pulses. The effects of PRF and overpressure on bubble dynamics and lifetimes were studied experimentally with passive cavitation detection, high-speed photography, and B-mode ultrasound and theoretically. Overpressure significantly reduced calculated (100-2 s) and measured (55-0.5 s) bubble lifetimes. At 1.5 bar static pressure, a dense bubble cluster was measured with clinically high PRF (2-3 Hz) and a sparse cluster with clinically low PRF (0.5-1 Hz), indicating bubble lifetimes of 0.5-1 s, consistent with calculations. In contrast to cavitation in water, high-speed photography showed that overpressure did not suppress cavitation of bubbles stabilized on a cracked surface. These results suggest that a judicious use of overpressure and PRF in lithotripsy could reduce cavitation damage of tissue while maintaining cavitation comminution of stones.
AB - Cavitation appears to contribute to tissue injury in lithotripsy. Reports have shown that increasing pulse repetition frequency [(PRF) 0.5-100 Hz] increases tissue damage and increasing static pressure (1-3 bar) reduces cell damage without decreasing stone comminution. Our hypothesis is that overpressure or slow PRF causes unstabilized bubbles produced by one shock pulse to dissolve before they nucleate cavitation by subsequent shock pulses. The effects of PRF and overpressure on bubble dynamics and lifetimes were studied experimentally with passive cavitation detection, high-speed photography, and B-mode ultrasound and theoretically. Overpressure significantly reduced calculated (100-2 s) and measured (55-0.5 s) bubble lifetimes. At 1.5 bar static pressure, a dense bubble cluster was measured with clinically high PRF (2-3 Hz) and a sparse cluster with clinically low PRF (0.5-1 Hz), indicating bubble lifetimes of 0.5-1 s, consistent with calculations. In contrast to cavitation in water, high-speed photography showed that overpressure did not suppress cavitation of bubbles stabilized on a cracked surface. These results suggest that a judicious use of overpressure and PRF in lithotripsy could reduce cavitation damage of tissue while maintaining cavitation comminution of stones.
UR - http://www.scopus.com/inward/record.url?scp=0036711820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036711820&partnerID=8YFLogxK
U2 - 10.1121/1.1500754
DO - 10.1121/1.1500754
M3 - Article
C2 - 12243163
AN - SCOPUS:0036711820
VL - 112
SP - 1183
EP - 1195
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
SN - 0001-4966
IS - 3 I
ER -