Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I

T. W. Stephens, G. A. Cook, R. A. Harris

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Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 μM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalBiochemical Journal
Issue number2
StatePublished - Jan 1 1983


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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