Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I

T. W. Stephens, G. A. Cook, Robert Harris

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 μM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalBiochemical Journal
Volume212
Issue number2
StatePublished - 1983

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Malonyl Coenzyme A
Carnitine O-Palmitoyltransferase
Ketosis
Fatty Acids
Oxidation
Liver

ASJC Scopus subject areas

  • Biochemistry

Cite this

Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I. / Stephens, T. W.; Cook, G. A.; Harris, Robert.

In: Biochemical Journal, Vol. 212, No. 2, 1983, p. 521-524.

Research output: Contribution to journalArticle

Stephens, T. W. ; Cook, G. A. ; Harris, Robert. / Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I. In: Biochemical Journal. 1983 ; Vol. 212, No. 2. pp. 521-524.
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