Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms

A. H. Teixeira, E. S. Pereira, L. K.A. Rodrigues, D. Saxena, S. Duarte, I. C.J. Zanin

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S -L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

Original languageEnglish (US)
Pages (from-to)549-554
Number of pages6
JournalCaries research
Volume46
Issue number6
DOIs
StatePublished - Dec 1 2012

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Keywords

  • Biofilms
  • In situ study
  • Photodynamic antimicrobial chemotherapy
  • Streptococcus mutans

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Teixeira, A. H., Pereira, E. S., Rodrigues, L. K. A., Saxena, D., Duarte, S., & Zanin, I. C. J. (2012). Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms. Caries research, 46(6), 549-554. https://doi.org/10.1159/000341190