Effect of prolonged uterine blood flow reduction on fetal growth in sheep

David Boyle, Sara Lecklitner, Edward A. Liechty

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The purpose of the present investigation was to study the effect of 7 days of uterine blood flow reduction on fetal growth. Reduction in uterine blood flow was accomplished by external occlusion of the terminal aorta in 20 pregnant sheep. Linear growth was monitored daily by means of a crown-rump length measuring device. The deliveries of oxygen, glucose, and lactate to the fetus, as well as their uptakes by the fetus, were determined before and after 7 days of uterine blood flow reduction and correlated with rates of fetal growth. Identical studies were conducted in nine control animals. Uterine blood flow reduction resulted in a significant decrease in fetal oxygen delivery and fetal arterial oxygen content. Linear growth rate decreased by 38% in the occluded animals during hypoxemia. In addition, there was a 20% reduction in daily weight gain in occluded animals compared with controls. There were no differences in the uptakes of oxygen, glucose, and lactate by the fetus. Positive correlations were found between linear growth rate and fetal arterial oxygen content (r2 = 0.25, P = 0.0001) and between linear growth rate and fetal oxygen delivery (r2 = 0.21, P = 0.0006). The correlations between linear growth rate and fetal oxygenation provide strong evidence of the central role of oxygen in the regulation of fetal growth.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume270
Issue number1 39-1
StatePublished - 1996

Fingerprint

Fetal Development
Sheep
Oxygen
Fetus
Lactic Acid
Crown-Rump Length
Glucose
Growth
Weight Gain
Aorta
Equipment and Supplies

Keywords

  • glucose uptake
  • hypoxemia
  • intrauterine growth retardation
  • lactate
  • limb metabolism
  • oxygen consumption

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effect of prolonged uterine blood flow reduction on fetal growth in sheep. / Boyle, David; Lecklitner, Sara; Liechty, Edward A.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 270, No. 1 39-1, 1996.

Research output: Contribution to journalArticle

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