Effect of protein intake on renal function and structure in partially nephrectomized rats

C. H. Kenner, Andrew Evan, P. Blomgren, G. R. Aronoff, F. C. Luft

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

To examine the effect of high protein intake on renal function and structure in rats with 5/6 nephrectomy chronic renal failure, we paired rats with chronic renal failure and sham-operated control rats diets of 14 or 37% protein content for up to 6 months. High protein intake accelerated mortality in rats with chronic renal failure and resulted in a more rapid rate of decrease in renal function as established by plotting the reciprocal of plasma creatinine versus time. High protein intake also increased urine protein excretion in experimental and control rats. High protein intake was associated with increased tubular dilatation and interstitial inflammation, both of which were striking features in rats with chronic renal failure. Glomerular sclerosis was prominent in rats with chronic renal failure. These rats had smaller glomerular tuft dimensions than control rats irrespective of their protein intake. We conclude that high protein intake accelerates the course of chronic renal failure in rats. The pathologic process involves glomerular sclerosis; however, interstitial inflammation and renal tubular changes leading to cyst formation also appear to influence the process adversely.

Original languageEnglish
Pages (from-to)739-750
Number of pages12
JournalKidney International
Volume27
Issue number5
StatePublished - 1985

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Kidney
Chronic Kidney Failure
Proteins
Sclerosis
Inflammation
Pathologic Processes
Nephrectomy
Cysts
Dilatation
Creatinine
Urine
Diet
Mortality

ASJC Scopus subject areas

  • Nephrology

Cite this

Kenner, C. H., Evan, A., Blomgren, P., Aronoff, G. R., & Luft, F. C. (1985). Effect of protein intake on renal function and structure in partially nephrectomized rats. Kidney International, 27(5), 739-750.

Effect of protein intake on renal function and structure in partially nephrectomized rats. / Kenner, C. H.; Evan, Andrew; Blomgren, P.; Aronoff, G. R.; Luft, F. C.

In: Kidney International, Vol. 27, No. 5, 1985, p. 739-750.

Research output: Contribution to journalArticle

Kenner, CH, Evan, A, Blomgren, P, Aronoff, GR & Luft, FC 1985, 'Effect of protein intake on renal function and structure in partially nephrectomized rats', Kidney International, vol. 27, no. 5, pp. 739-750.
Kenner, C. H. ; Evan, Andrew ; Blomgren, P. ; Aronoff, G. R. ; Luft, F. C. / Effect of protein intake on renal function and structure in partially nephrectomized rats. In: Kidney International. 1985 ; Vol. 27, No. 5. pp. 739-750.
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