Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol

M. Schwaiger, H. Guibourg, K. Rosenspire, T. McClanahan, K. Gallagher, G. Hutchins, D. M. Wieland

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

With the introduction of radiolabeled catecholamine analogues, the noninvasive evaluation of the cardiac sympathetic nervous system has become possible. This study evaluated the effect of regional ischemia on myocardial retention of the new norepinephrine analogue 6-[18F]fluorometaraminol (FMR) in the open chest dog model. Six dogs were injected intravenously with FMR following 30-min occlusion of the left anterior descending artery. Six sham animals served as control group. Regional myocardial blood flow as determined by microspherers decreased 87% during ischemia (p < 0.01), but was not significantly different from control myocardium following reperfusion. Regional myocardial 18F activity as determined postmortem was significantly reduced in reperfused myocardium (-34%), which paralleled an 18% reduction of tissue norepinephrine concentration. Thus, short time periods of coronary occlusion affect neuronal function indicating the sensitivity of the sympathetic nerve terminals to ischemia. FMR provides a new tracer approach for the characterization of neuronal integrity in postischemic myocardium.

Original languageEnglish (US)
Pages (from-to)1352-1357
Number of pages6
JournalJournal of Nuclear Medicine
Volume31
Issue number8
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Schwaiger, M., Guibourg, H., Rosenspire, K., McClanahan, T., Gallagher, K., Hutchins, G., & Wieland, D. M. (1990). Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol. Journal of Nuclear Medicine, 31(8), 1352-1357.