Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: A pilot study

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Abstract

Purpose We performed a pilot study to assess whether renal shock wave lithotripsy influences metabolic syndrome onset and severity. Materials and Methods Three-month-old juvenile female Ossabaw miniature pigs were treated with shock wave lithotripsy (2,000 shock waves at 24 kV with 120 shock waves per minute in 2) or sham shock wave lithotripsy (no shock waves in 2). Shock waves were targeted to the upper pole of the left kidney to model treatment that would also expose the pancreatic tail to shock waves. Pigs were then instrumented to directly measure arterial blood pressure via an implanted radiotelemetry device. They later received a hypercaloric atherogenic diet for about 7 months. Metabolic syndrome development was assessed by the intravenous glucose tolerance test. Results Metabolic syndrome progression and severity were similar in the sham treated and lithotripsy groups. The only exception arterial blood pressure, which remained relatively constant in sham treated pigs but began to increase at about 2 months towards hypertensive levels in lithotripsy treated pigs. Metabolic data on the 2 groups were pooled to provide a more complete assessment of metabolic syndrome development and progression in this juvenile pig model. The intravenous glucose tolerance test revealed substantial insulin resistance with impaired glucose tolerance within 2 months on the hypercaloric atherogenic diet with signs of further metabolic impairment at 7 months. Conclusions These preliminary results suggest that renal shock wave lithotripsy is not a risk factor for worsening glucose tolerance or diabetes mellitus onset. However, it appears to be a risk factor for early onset hypertension in metabolic syndrome.

Original languageEnglish
Pages (from-to)1409-1416
Number of pages8
JournalJournal of Urology
Volume193
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Lithotripsy
Swine
Kidney
Atherogenic Diet
Glucose Tolerance Test
Arterial Pressure
Glucose Intolerance
Insulin Resistance
Tail
Diabetes Mellitus
Hypertension
Glucose
Equipment and Supplies

Keywords

  • hypertension
  • kidney
  • lithotripsy
  • metabolic syndrome X
  • risk

ASJC Scopus subject areas

  • Urology

Cite this

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title = "Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: A pilot study",
abstract = "Purpose We performed a pilot study to assess whether renal shock wave lithotripsy influences metabolic syndrome onset and severity. Materials and Methods Three-month-old juvenile female Ossabaw miniature pigs were treated with shock wave lithotripsy (2,000 shock waves at 24 kV with 120 shock waves per minute in 2) or sham shock wave lithotripsy (no shock waves in 2). Shock waves were targeted to the upper pole of the left kidney to model treatment that would also expose the pancreatic tail to shock waves. Pigs were then instrumented to directly measure arterial blood pressure via an implanted radiotelemetry device. They later received a hypercaloric atherogenic diet for about 7 months. Metabolic syndrome development was assessed by the intravenous glucose tolerance test. Results Metabolic syndrome progression and severity were similar in the sham treated and lithotripsy groups. The only exception arterial blood pressure, which remained relatively constant in sham treated pigs but began to increase at about 2 months towards hypertensive levels in lithotripsy treated pigs. Metabolic data on the 2 groups were pooled to provide a more complete assessment of metabolic syndrome development and progression in this juvenile pig model. The intravenous glucose tolerance test revealed substantial insulin resistance with impaired glucose tolerance within 2 months on the hypercaloric atherogenic diet with signs of further metabolic impairment at 7 months. Conclusions These preliminary results suggest that renal shock wave lithotripsy is not a risk factor for worsening glucose tolerance or diabetes mellitus onset. However, it appears to be a risk factor for early onset hypertension in metabolic syndrome.",
keywords = "hypertension, kidney, lithotripsy, metabolic syndrome X, risk",
author = "Rajash Handa and Ziyue Liu and Connors, {Bret A.} and Mouhamad Alloosh and David Basile and Johnathan Tune and Michael Sturek and Andrew Evan and Lingeman, {James E.}",
year = "2015",
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language = "English",
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T1 - Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model

T2 - A pilot study

AU - Handa, Rajash

AU - Liu, Ziyue

AU - Connors, Bret A.

AU - Alloosh, Mouhamad

AU - Basile, David

AU - Tune, Johnathan

AU - Sturek, Michael

AU - Evan, Andrew

AU - Lingeman, James E.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Purpose We performed a pilot study to assess whether renal shock wave lithotripsy influences metabolic syndrome onset and severity. Materials and Methods Three-month-old juvenile female Ossabaw miniature pigs were treated with shock wave lithotripsy (2,000 shock waves at 24 kV with 120 shock waves per minute in 2) or sham shock wave lithotripsy (no shock waves in 2). Shock waves were targeted to the upper pole of the left kidney to model treatment that would also expose the pancreatic tail to shock waves. Pigs were then instrumented to directly measure arterial blood pressure via an implanted radiotelemetry device. They later received a hypercaloric atherogenic diet for about 7 months. Metabolic syndrome development was assessed by the intravenous glucose tolerance test. Results Metabolic syndrome progression and severity were similar in the sham treated and lithotripsy groups. The only exception arterial blood pressure, which remained relatively constant in sham treated pigs but began to increase at about 2 months towards hypertensive levels in lithotripsy treated pigs. Metabolic data on the 2 groups were pooled to provide a more complete assessment of metabolic syndrome development and progression in this juvenile pig model. The intravenous glucose tolerance test revealed substantial insulin resistance with impaired glucose tolerance within 2 months on the hypercaloric atherogenic diet with signs of further metabolic impairment at 7 months. Conclusions These preliminary results suggest that renal shock wave lithotripsy is not a risk factor for worsening glucose tolerance or diabetes mellitus onset. However, it appears to be a risk factor for early onset hypertension in metabolic syndrome.

AB - Purpose We performed a pilot study to assess whether renal shock wave lithotripsy influences metabolic syndrome onset and severity. Materials and Methods Three-month-old juvenile female Ossabaw miniature pigs were treated with shock wave lithotripsy (2,000 shock waves at 24 kV with 120 shock waves per minute in 2) or sham shock wave lithotripsy (no shock waves in 2). Shock waves were targeted to the upper pole of the left kidney to model treatment that would also expose the pancreatic tail to shock waves. Pigs were then instrumented to directly measure arterial blood pressure via an implanted radiotelemetry device. They later received a hypercaloric atherogenic diet for about 7 months. Metabolic syndrome development was assessed by the intravenous glucose tolerance test. Results Metabolic syndrome progression and severity were similar in the sham treated and lithotripsy groups. The only exception arterial blood pressure, which remained relatively constant in sham treated pigs but began to increase at about 2 months towards hypertensive levels in lithotripsy treated pigs. Metabolic data on the 2 groups were pooled to provide a more complete assessment of metabolic syndrome development and progression in this juvenile pig model. The intravenous glucose tolerance test revealed substantial insulin resistance with impaired glucose tolerance within 2 months on the hypercaloric atherogenic diet with signs of further metabolic impairment at 7 months. Conclusions These preliminary results suggest that renal shock wave lithotripsy is not a risk factor for worsening glucose tolerance or diabetes mellitus onset. However, it appears to be a risk factor for early onset hypertension in metabolic syndrome.

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KW - risk

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