Effect of repeated methamphetamine administrations on dopamine and glutamate efflux in rat prefrontal cortex

Stacy E. Stephans, Bryan Yamamoto

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Pretreatment with psychostimulants such as methamphetamine (METH) results in augmented mesostriatal dopamine transmission upon a challenge administration of the drug. This effect can be blocked by dopamine antagonists and excitatory amino acid antagonists. However, no direct comparisons have been made with respect to the effects of a low-dose pretreatment regimen of METH on impulse and transporter-mediated dopamine release or to what extent glutamate release is altered by a pretreatment regimen with METH. The purpose of this study was to examine dopamine and glutamate efflux in the prefrontal cortex and striatum in rats pretreated with METH following either high potassium (80 mM) infusion or after a systemic injection of a low dose of METH. Extracellular dopamine and glutamate concentrations in the prefrontal cortex and striatum were measured in vivo by microdialysis. Potassium infusion increased extracellular dopamine and glutamate concentrations to a greater extent in the prefrontal cortex than in the striatum of METH-pretreated rats compared to saline-pretreated controls. A low dose METH challenge significantly increased extracellular dopamine but not glutamate concentrations in both prefrontal cortex and striatum of all animals. Moreover, the acute METH-induced increase in cortical dopamine efflux was significantly greater in rats pretreated with METH. Overall, these data are the first evidence that repeated METH administrations can enhance cortical glutamate efflux and indicate that a low dose pretreatment regimen of METH enhances dopamine transmission in the prefrontal cortex through both transporter and depolarization-induced mechanisms.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalBrain Research
Volume700
Issue number1-2
DOIs
StatePublished - Nov 27 1995
Externally publishedYes

Fingerprint

Methamphetamine
Prefrontal Cortex
Glutamic Acid
Dopamine
Potassium
Excitatory Amino Acid Antagonists
Dopamine Plasma Membrane Transport Proteins
Dopamine Antagonists
Microdialysis

Keywords

  • Cortex
  • Dopamine
  • Glutamate
  • Methamphetamine
  • Microdialysis
  • Striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of repeated methamphetamine administrations on dopamine and glutamate efflux in rat prefrontal cortex. / Stephans, Stacy E.; Yamamoto, Bryan.

In: Brain Research, Vol. 700, No. 1-2, 27.11.1995, p. 99-106.

Research output: Contribution to journalArticle

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