Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat

J. B. Watkins, C. D. Klaassen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of repeated administration of taurocholate on bile acid pool size, biliary composition and biliary excretory capacity for bile acids and two xenobiotics was determined. The bile acid pool was increased 50 to 60% by oral administration of sodium taurocholate (300-900 mg/kg, 10 ml/kg) every 12 hr for 2 days to male Sprague-Dawley rats. Bile flow, biliary excretion of bile acids, cholesterol and phospholipid and the concentrations of phospholipid and bile acids in bile were increased in rats treated with 750 mg of taurocholate per kg. No effect was observed on Na+,K+ or Cl- levels. The biliary transport maximum for taurocholate was increased by 30% in rats treated with 750 mg/kg. In contrast, the plasma disappearance and biliary excretion of phenol-3,6-dibromphthalein and ouabain were not affected by taurocholate administration.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume218
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Taurocholic Acid
Bile Acids and Salts
Oral Administration
Liver
Bile
Phospholipids
Xenobiotics
Ouabain
Phenol
Sprague Dawley Rats
Cholesterol

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat. / Watkins, J. B.; Klaassen, C. D.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 218, No. 1, 1981, p. 182-187.

Research output: Contribution to journalArticle

@article{8e011fc6216b4f4db26fbc29e7de249b,
title = "Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat",
abstract = "The effect of repeated administration of taurocholate on bile acid pool size, biliary composition and biliary excretory capacity for bile acids and two xenobiotics was determined. The bile acid pool was increased 50 to 60{\%} by oral administration of sodium taurocholate (300-900 mg/kg, 10 ml/kg) every 12 hr for 2 days to male Sprague-Dawley rats. Bile flow, biliary excretion of bile acids, cholesterol and phospholipid and the concentrations of phospholipid and bile acids in bile were increased in rats treated with 750 mg of taurocholate per kg. No effect was observed on Na+,K+ or Cl- levels. The biliary transport maximum for taurocholate was increased by 30{\%} in rats treated with 750 mg/kg. In contrast, the plasma disappearance and biliary excretion of phenol-3,6-dibromphthalein and ouabain were not affected by taurocholate administration.",
author = "Watkins, {J. B.} and Klaassen, {C. D.}",
year = "1981",
language = "English (US)",
volume = "218",
pages = "182--187",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "1",

}

TY - JOUR

T1 - Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat

AU - Watkins, J. B.

AU - Klaassen, C. D.

PY - 1981

Y1 - 1981

N2 - The effect of repeated administration of taurocholate on bile acid pool size, biliary composition and biliary excretory capacity for bile acids and two xenobiotics was determined. The bile acid pool was increased 50 to 60% by oral administration of sodium taurocholate (300-900 mg/kg, 10 ml/kg) every 12 hr for 2 days to male Sprague-Dawley rats. Bile flow, biliary excretion of bile acids, cholesterol and phospholipid and the concentrations of phospholipid and bile acids in bile were increased in rats treated with 750 mg of taurocholate per kg. No effect was observed on Na+,K+ or Cl- levels. The biliary transport maximum for taurocholate was increased by 30% in rats treated with 750 mg/kg. In contrast, the plasma disappearance and biliary excretion of phenol-3,6-dibromphthalein and ouabain were not affected by taurocholate administration.

AB - The effect of repeated administration of taurocholate on bile acid pool size, biliary composition and biliary excretory capacity for bile acids and two xenobiotics was determined. The bile acid pool was increased 50 to 60% by oral administration of sodium taurocholate (300-900 mg/kg, 10 ml/kg) every 12 hr for 2 days to male Sprague-Dawley rats. Bile flow, biliary excretion of bile acids, cholesterol and phospholipid and the concentrations of phospholipid and bile acids in bile were increased in rats treated with 750 mg of taurocholate per kg. No effect was observed on Na+,K+ or Cl- levels. The biliary transport maximum for taurocholate was increased by 30% in rats treated with 750 mg/kg. In contrast, the plasma disappearance and biliary excretion of phenol-3,6-dibromphthalein and ouabain were not affected by taurocholate administration.

UR - http://www.scopus.com/inward/record.url?scp=0019452113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019452113&partnerID=8YFLogxK

M3 - Article

C2 - 7241377

AN - SCOPUS:0019452113

VL - 218

SP - 182

EP - 187

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 1

ER -