Effect of shock wave lithotripsy on renal hemodynamics

Rajash K. Handa, Lynn R. Willis, Andrew P. Evan, Bret A. Connors

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Extracorporeal shock wave lithotripsy (SWL) can injure tissue and decrease blood flow in the SWL-treated kidney, both tissue and functional effects being largely localized to the region targeted with shock waves (SWs). A novel method of limiting SWL-induced tissue injury is to employ the "protection" protocol, where the kidney is pretreated with low-energy SWs prior to the application of a standard clinical dose of high-energy SWs. Resistive index measurements of renal vascular resistance/impedance to blood flow during SWL treatment protocols revealed that a standard clinical dose of high-energy SWs did not alter RI during SW application. However, there was an interaction between low- and high-energy SWL treatment phases of the "protection" protocol such that an increase in RI (vasoconstriction) was observed during the later half of SW application, a time when tissue damage is occurring during the standard high-energy SWL protocol. We suggest that renal vasoconstriction may be responsible for reducing the degree of tissue damage that normally results from a standard clinical dose of high-energy SWs.

Original languageEnglish (US)
Title of host publicationRenal Stone Disease 2 - 2nd International Urolithiasis Research Symposium
Pages249-255
Number of pages7
DOIs
StatePublished - Oct 22 2008
Event2nd International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Apr 17 2008Apr 18 2008

Publication series

NameAIP Conference Proceedings
Volume1049
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other2nd International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period4/17/084/18/08

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Keywords

  • "protection" protocol
  • Extracorporeal shock wave lithotripsy
  • PET imaging
  • Resistive index
  • Sonography

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Handa, R. K., Willis, L. R., Evan, A. P., & Connors, B. A. (2008). Effect of shock wave lithotripsy on renal hemodynamics. In Renal Stone Disease 2 - 2nd International Urolithiasis Research Symposium (pp. 249-255). (AIP Conference Proceedings; Vol. 1049). https://doi.org/10.1063/1.2998031