Effect of sucralfate against hydrochloric acid-induced dental erosion

Cecilia P. Turssi, Flávia L.B. Amaral, Fabiana M.G. França, Roberta T. Basting, Anderson T. Hara

Research output: Contribution to journalArticle

1 Scopus citations


Objective: Devising effective measures for the prevention of hydrochloric acid (HCl)-induced erosion is of great significance. This is even more important in dentine, in which products have limited diffusion. Therefore, agents that can bind to proteins forming an acid-resistant gel-like coat, such as sucralfate, may stand out as a promising alternative. This study investigated the protective effect of sucralfate suspensions against HCl-induced dental erosion. Materials and methods: In the first experiment, hydroxyapatite (HAp) crystals were pre-treated with a commercial sucralfate suspension (CoSS, pH 5.9), a stannous-containing sodium fluoride solution (NaF/SnCl 2 pH 4.5), two prepared sucralfate suspensions (PrSS, pH 5.9 and 4.5), or deionized water (DI, control). HAp dissolution was measured using a pH-stat system. In a subsequent experiment, embedded/polished enamel and root dentine slabs were allocated into five groups to be treated with one of the tested substances prior to and during erosion-remineralization cycles (HCl-2 min + artificial saliva 60 min, two times per day, 5 days). Surface loss was assessed profilometrically. Data were analyzed by ANOVA and Tukey’s tests. Results: HAp dissolution was as follows: NaF/SnCl 2 < CoSS < PrSS/pH 4.5, while PrSS/pH 5.9 = DI and both did not differ from CoSS and PrSS/pH 4.5. In enamel, surface loss did not differ between CoSS and PrSS/pH 4.5, with both having lower surface loss than PrSS/pH 5.9 and DI and NaF/SnCl 2 differing only from DI. In root dentine, surface loss was as follows: CoSS < PrSS/pH 5.9 < (NaF/SnCl 2 = DI), while PrSS/pH 4.5 = CoSS = PrSS/pH 5.9. Conclusion: Sucralfate suspension provided anti-erosive protection to HCl-induced erosion. Clinical relevance: Sucralfate may protect teeth against erosion caused by gastric acid.

Original languageEnglish (US)
Pages (from-to)2365-2370
Number of pages6
JournalClinical oral investigations
Issue number5
StatePublished - May 1 2019


  • Dental erosion
  • Dentine
  • Enamel
  • Sucralfate
  • Surface loss

ASJC Scopus subject areas

  • Dentistry(all)

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