Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury

Thomas W. McAllister, C. Harker Rhodes, Laura A. Flashman, Brenna McDonald, Dorothy Belloni, Andrew Saykin

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury. Method: Thirty-nine patients with mild traumatic brain injury and 27 comparison subjects were genotyped. All subjects completed memory and attention tests, including the California Verbal Learning Test recognition task and the Continuous Performance Test. Results: In both groups the T allele was associated with poorer performance on the California Verbal Learning Test recognition task. There was also a significant diagnosis-by-allele interaction on measures of response latency (Continuous Performance Test): the subjects with mild traumatic brain injury and the T allele had the worst performance. Conclusions: Genetic polymorphisms modulating central dopaminergic tone can affect cognitive outcome following mild traumatic brain injury.

Original languageEnglish (US)
Pages (from-to)1749-1751
Number of pages3
JournalAmerican Journal of Psychiatry
Volume162
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

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Brain Concussion
Dopamine D2 Receptors
Reaction Time
Alleles
Verbal Learning
Task Performance and Analysis
Genetic Polymorphisms

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. / McAllister, Thomas W.; Rhodes, C. Harker; Flashman, Laura A.; McDonald, Brenna; Belloni, Dorothy; Saykin, Andrew.

In: American Journal of Psychiatry, Vol. 162, No. 9, 09.2005, p. 1749-1751.

Research output: Contribution to journalArticle

McAllister, Thomas W. ; Rhodes, C. Harker ; Flashman, Laura A. ; McDonald, Brenna ; Belloni, Dorothy ; Saykin, Andrew. / Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. In: American Journal of Psychiatry. 2005 ; Vol. 162, No. 9. pp. 1749-1751.
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