Effect of the fluorinated gases SF6 and C3F8 on ocular tissues following laser treatment

M. Boulton, M. R.C. Capon, J. Mellerio, M. F.P. Griffiths, M. Bayly, J. I. Krafft

Research output: Contribution to journalArticle


During intraocular injection of sulfahexafluoride (SF6) or perfluoropropane (C3F8) gases in vitreoretinal procedures, complications may arise if many small bubbles form within the eye. It has been suggested that to overcome this problem an Nd:YAG laser can be used to form plasmas within the bubbles causing them to coalesce. To determine the safety of forming plasmas within fluorinated gases we have examined the effect of photodisruption of these gases while in contact with cultured cells. Marked cell damage and drop-out occurred when plasmas were formed in the fluorinated gases SF6 and C3F8, but no cell damage was seen when air was the lasered medium. The damage appeared to be most severe following the photodisruption of SF6. In contrast, argon (continuous wave) laser irradiation of pigmented cells in contact with the fluorinated gases did not induce damage greater than air.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalLasers and Light in Ophthalmology
Issue number3
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Ophthalmology

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    Boulton, M., Capon, M. R. C., Mellerio, J., Griffiths, M. F. P., Bayly, M., & Krafft, J. I. (1989). Effect of the fluorinated gases SF6 and C3F8 on ocular tissues following laser treatment. Lasers and Light in Ophthalmology, 2(3), 183-191.