Effect of time interval on residual disease in breast cancer

Elizabeth L. Wiley, Leslie K. Diaz, Sunil Badve, Monica Morrow

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The histologic responses of breast tissue to injury are limited. Needle core biopsies of the breast are associated with displacement of tumor cells, and the incidence of tumor displacement decreases as the time interval between needle core biopsy and subsequent excision increases. This suggests that displaced tumor cells are destroyed by reparative processes induced by tissue injury. Residual tumor in a lumpectomy site may also be subjected to the same destructive processes associated with tissue repair. A total of 259 consecutive cases of infiltrating ductal carcinoma with margin-positive lumpectomies and their associated reexcision specimens obtained over a 7-year period were analyzed for the presence, type, and quantity of residual disease. The overall incidence of residual disease was 69%. Residual infiltrating ductal carcinoma was present in 35% of cases, and residual ductal carcinoma in situ was present in 50%. An increased time interval between lumpectomy and reexcision was associated with a decreased incidence of residual infiltrating carcinoma (p <0.0043); this decrease was not found associated with ductal carcinoma in situ. These findings suggest that the host response to injury may destroy residual infiltrating carcinoma cells in some margin-positive cases.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Segmental Mastectomy
Large-Core Needle Biopsy
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Incidence
Wounds and Injuries
Breast
Carcinoma
Neoplasms
Residual Neoplasm

Keywords

  • Breast
  • Carcinoma
  • Margin
  • Residual disease

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Effect of time interval on residual disease in breast cancer. / Wiley, Elizabeth L.; Diaz, Leslie K.; Badve, Sunil; Morrow, Monica.

In: American Journal of Surgical Pathology, Vol. 27, No. 2, 01.02.2003, p. 194-198.

Research output: Contribution to journalArticle

Wiley, Elizabeth L. ; Diaz, Leslie K. ; Badve, Sunil ; Morrow, Monica. / Effect of time interval on residual disease in breast cancer. In: American Journal of Surgical Pathology. 2003 ; Vol. 27, No. 2. pp. 194-198.
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