Effect of Topical Flurbiprofen on Trabeculectomy

Louis B. Cantor, Cheryl A. Phillips, David Kramer, Robert J. Boeglin, Amita Manatunga, Eleanor Holleman

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Purpose and Methods: The effect of topical flurbiprofen, in addition to our ususal topical postoperative medications (prednisolone 1%, phenylephrine 2.5%, atropine 1%, and gentamycin 0.3%), on the outcome of trabeculectomy was assessed in a prospective, placebo-controlled, randomized study of 49 eyes. Mean postoperative follow-up was 42 weeks (range, 4-52 weeks). Results: Intraocular pressure was higher in the flurbiprofen (Ocufen, Allergan Pharmaceuticals) treated eyes than in the placebo control eyes, but they are not significantly different (15.7 ± 1.1 vs. 12.8 ± 1.2 mm Hg, p = 0.20, mean ± SE). Similar results were observed for visual acuity using the Log-MAR scale (−0.45 ± 0.06 vs. −0.52 ± 0.07, p = 0.42, mean ± SE). For both visual acuity and intraocular pressure, the flubiprofen effect did not change significantly with the follow-up period. There were more encapsulated filtering blebs in flurbiprofen-treated eyes (11/24 eyes, 46%) than in eyes treated with the artificial tear placebo (5/25 eyes, 20%), though the difference was only marginally significant (p = 0.058). No other differences in adverse effects were noted between the two groups. Conclusion: These results suggest that there is no benefit of using postoperative flurbiprofen following initial trabeculectomy surgery.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalJournal of glaucoma
Issue number2
StatePublished - Apr 1995


  • Cyclo-oxygenase inhibitors
  • Flurbiprofen
  • Nonsteroidal anti-inflammatory agents
  • Trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

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    Cantor, L. B., Phillips, C. A., Kramer, D., Boeglin, R. J., Manatunga, A., & Holleman, E. (1995). Effect of Topical Flurbiprofen on Trabeculectomy. Journal of glaucoma, 4(2), 98-102. https://doi.org/10.1097/00061198-199504000-00006