Effect of transpulmonary pressure on airway closure in immature and mature rabbits

Robert Tepper, Susan Gunst, C. M. Doerschuk, X. Shen, W. Bray

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The transpulmonary pressures (Ptp values) at which airway closure occurred during maximal stimulation with methacholine were compared in 10 mature and 9 immature rabbit lungs by using an alveolar capsule technique to assess airway closure. After maximal constriction, airway opening and alveolar capsule pressures were recorded during small volume oscillations as Ptp was lowered from 12 to 4 cmH2O. At each Ptp, the proportion of alveolar capsules indicating airway closure was greater for the immature than for the mature lungs (P < 0.025). At Ptp of 4 cmH2O, only 20% of alveolar capsules indicated airway closure in the mature lungs in contrast to 85% indicating closure in the immature lungs (P < 0.001). The in vitro sensitivity of tracheal smooth muscle to acetylcholine and histamine was greater in tissues from immature than from mature rabbits. We conclude that the more frequent airway closure observed in immature rabbits could reflect maturational differences in the structure of the bronchi or lung parenchyma or differences in the coupling between the parenchyma and the airways.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalJournal of Applied Physiology
Volume78
Issue number2
StatePublished - 1995

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Capsules
Rabbits
Pressure
Lung
Methacholine Chloride
Bronchi
Constriction
Histamine
Acetylcholine
Smooth Muscle

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of transpulmonary pressure on airway closure in immature and mature rabbits. / Tepper, Robert; Gunst, Susan; Doerschuk, C. M.; Shen, X.; Bray, W.

In: Journal of Applied Physiology, Vol. 78, No. 2, 1995, p. 505-512.

Research output: Contribution to journalArticle

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