Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations

Helen T. Winer-Muram, S. Gregory Jennings, Cristopher A. Meyer, Yun Liang, Alex M. Aisen, Robert D. Tarver, Ronald C. McGarry

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine how volume measurements of simulated and clinical lung tumors at standard computed tomographic (CT) lung window and level settings vary with section width and to derive and apply compensatory equations. MATERIALS AND METHODS: Spherical simulated tumors of varying diameters were imaged with varying CT section widths, the images were displayed on a workstation, the cross-sectional area of the tumor on each section was measured by using elliptical and perimeter methods, and the areas were integrated to compute tumor volume. The actual and measured tumor volumes for differing section widths and tumor diameters were compared, and compensatory equations were derived. The equations were applied to contemporaneous chest CT images obtained in patients with stage I lung cancer, and the difference between thick- and thin-section-derived volumes before and after application of the equations was determined. RESULTS: All simulated tumor volumes were overestimated 11 %-278%; overestimation varied directly with section width and inversely with tumor diameter. With both measurement methods, mean thin-section volumes of clinical tumors in 55 patients were significantly smaller (P < .01) than mean thick-section volumes: Mean elliptical measurements were 15,025 mm 3 (thin) and 18,037 mm3 (thick), with a 20.0% difference; mean perimeter measurements were 16,164 mm3 (thin) and 20,718 mm 3 (thick), with a 22.2% difference. The thin-section-to-thick-section volume difference was larger for the smallest tumors. Thin-section volumes were smaller than thick-section volumes in 53 patients with the elliptical method and in 51 patients with the perimeter method. Applying the equations decreased the difference between thick- and thin-section volumes in 37 (67%) of the 55 patients with the elliptical method and in 41 (74%) patients with the perimeter method. The mean thin-section-to-thick-section volume difference became nonsignificant with the perimeter method but remained significant with the elliptical method. CONCLUSION: Measured lung tumor volumes vary significantly with varying CT section width; overestimation varies directly with section width and inversely with tumor size. Compensatory equations that are somewhat effective in reducing these effects can be derived.

Original languageEnglish
Pages (from-to)184-194
Number of pages11
JournalRadiology
Volume229
Issue number1
DOIs
StatePublished - Oct 1 2003

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Tumor Burden
Lung
Neoplasms
Lung Neoplasms
Thorax

Keywords

  • Computed tomography (CT)
  • Experimental studies
  • Lung neoplasms
  • Lung neoplasms, CT
  • Thorax, CT

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Winer-Muram, H. T., Jennings, S. G., Meyer, C. A., Liang, Y., Aisen, A. M., Tarver, R. D., & McGarry, R. C. (2003). Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations. Radiology, 229(1), 184-194. https://doi.org/10.1148/radiol.2291020859

Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations. / Winer-Muram, Helen T.; Jennings, S. Gregory; Meyer, Cristopher A.; Liang, Yun; Aisen, Alex M.; Tarver, Robert D.; McGarry, Ronald C.

In: Radiology, Vol. 229, No. 1, 01.10.2003, p. 184-194.

Research output: Contribution to journalArticle

Winer-Muram, HT, Jennings, SG, Meyer, CA, Liang, Y, Aisen, AM, Tarver, RD & McGarry, RC 2003, 'Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations', Radiology, vol. 229, no. 1, pp. 184-194. https://doi.org/10.1148/radiol.2291020859
Winer-Muram, Helen T. ; Jennings, S. Gregory ; Meyer, Cristopher A. ; Liang, Yun ; Aisen, Alex M. ; Tarver, Robert D. ; McGarry, Ronald C. / Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations. In: Radiology. 2003 ; Vol. 229, No. 1. pp. 184-194.
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abstract = "PURPOSE: To determine how volume measurements of simulated and clinical lung tumors at standard computed tomographic (CT) lung window and level settings vary with section width and to derive and apply compensatory equations. MATERIALS AND METHODS: Spherical simulated tumors of varying diameters were imaged with varying CT section widths, the images were displayed on a workstation, the cross-sectional area of the tumor on each section was measured by using elliptical and perimeter methods, and the areas were integrated to compute tumor volume. The actual and measured tumor volumes for differing section widths and tumor diameters were compared, and compensatory equations were derived. The equations were applied to contemporaneous chest CT images obtained in patients with stage I lung cancer, and the difference between thick- and thin-section-derived volumes before and after application of the equations was determined. RESULTS: All simulated tumor volumes were overestimated 11 {\%}-278{\%}; overestimation varied directly with section width and inversely with tumor diameter. With both measurement methods, mean thin-section volumes of clinical tumors in 55 patients were significantly smaller (P < .01) than mean thick-section volumes: Mean elliptical measurements were 15,025 mm 3 (thin) and 18,037 mm3 (thick), with a 20.0{\%} difference; mean perimeter measurements were 16,164 mm3 (thin) and 20,718 mm 3 (thick), with a 22.2{\%} difference. The thin-section-to-thick-section volume difference was larger for the smallest tumors. Thin-section volumes were smaller than thick-section volumes in 53 patients with the elliptical method and in 51 patients with the perimeter method. Applying the equations decreased the difference between thick- and thin-section volumes in 37 (67{\%}) of the 55 patients with the elliptical method and in 41 (74{\%}) patients with the perimeter method. The mean thin-section-to-thick-section volume difference became nonsignificant with the perimeter method but remained significant with the elliptical method. CONCLUSION: Measured lung tumor volumes vary significantly with varying CT section width; overestimation varies directly with section width and inversely with tumor size. Compensatory equations that are somewhat effective in reducing these effects can be derived.",
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AU - Jennings, S. Gregory

AU - Meyer, Cristopher A.

AU - Liang, Yun

AU - Aisen, Alex M.

AU - Tarver, Robert D.

AU - McGarry, Ronald C.

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N2 - PURPOSE: To determine how volume measurements of simulated and clinical lung tumors at standard computed tomographic (CT) lung window and level settings vary with section width and to derive and apply compensatory equations. MATERIALS AND METHODS: Spherical simulated tumors of varying diameters were imaged with varying CT section widths, the images were displayed on a workstation, the cross-sectional area of the tumor on each section was measured by using elliptical and perimeter methods, and the areas were integrated to compute tumor volume. The actual and measured tumor volumes for differing section widths and tumor diameters were compared, and compensatory equations were derived. The equations were applied to contemporaneous chest CT images obtained in patients with stage I lung cancer, and the difference between thick- and thin-section-derived volumes before and after application of the equations was determined. RESULTS: All simulated tumor volumes were overestimated 11 %-278%; overestimation varied directly with section width and inversely with tumor diameter. With both measurement methods, mean thin-section volumes of clinical tumors in 55 patients were significantly smaller (P < .01) than mean thick-section volumes: Mean elliptical measurements were 15,025 mm 3 (thin) and 18,037 mm3 (thick), with a 20.0% difference; mean perimeter measurements were 16,164 mm3 (thin) and 20,718 mm 3 (thick), with a 22.2% difference. The thin-section-to-thick-section volume difference was larger for the smallest tumors. Thin-section volumes were smaller than thick-section volumes in 53 patients with the elliptical method and in 51 patients with the perimeter method. Applying the equations decreased the difference between thick- and thin-section volumes in 37 (67%) of the 55 patients with the elliptical method and in 41 (74%) patients with the perimeter method. The mean thin-section-to-thick-section volume difference became nonsignificant with the perimeter method but remained significant with the elliptical method. CONCLUSION: Measured lung tumor volumes vary significantly with varying CT section width; overestimation varies directly with section width and inversely with tumor size. Compensatory equations that are somewhat effective in reducing these effects can be derived.

AB - PURPOSE: To determine how volume measurements of simulated and clinical lung tumors at standard computed tomographic (CT) lung window and level settings vary with section width and to derive and apply compensatory equations. MATERIALS AND METHODS: Spherical simulated tumors of varying diameters were imaged with varying CT section widths, the images were displayed on a workstation, the cross-sectional area of the tumor on each section was measured by using elliptical and perimeter methods, and the areas were integrated to compute tumor volume. The actual and measured tumor volumes for differing section widths and tumor diameters were compared, and compensatory equations were derived. The equations were applied to contemporaneous chest CT images obtained in patients with stage I lung cancer, and the difference between thick- and thin-section-derived volumes before and after application of the equations was determined. RESULTS: All simulated tumor volumes were overestimated 11 %-278%; overestimation varied directly with section width and inversely with tumor diameter. With both measurement methods, mean thin-section volumes of clinical tumors in 55 patients were significantly smaller (P < .01) than mean thick-section volumes: Mean elliptical measurements were 15,025 mm 3 (thin) and 18,037 mm3 (thick), with a 20.0% difference; mean perimeter measurements were 16,164 mm3 (thin) and 20,718 mm 3 (thick), with a 22.2% difference. The thin-section-to-thick-section volume difference was larger for the smallest tumors. Thin-section volumes were smaller than thick-section volumes in 53 patients with the elliptical method and in 51 patients with the perimeter method. Applying the equations decreased the difference between thick- and thin-section volumes in 37 (67%) of the 55 patients with the elliptical method and in 41 (74%) patients with the perimeter method. The mean thin-section-to-thick-section volume difference became nonsignificant with the perimeter method but remained significant with the elliptical method. CONCLUSION: Measured lung tumor volumes vary significantly with varying CT section width; overestimation varies directly with section width and inversely with tumor size. Compensatory equations that are somewhat effective in reducing these effects can be derived.

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