Effect of ventilation with soluble and diffusible gases on the size of air emboli

Robert Presson, K. R. Kirk, K. A. Haselby, W. W. Wagner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pulmonary hypertension resulting from venous air embolism is known to increase after ventilation with highly soluble and diffusible gases. Exacerbation of the hypertension could be due to further blockage of the circulation if the bubbles enlarge as a result of ingress of gas by diffusion. This mechanism has been frequently cited but lacks direct proof. To determine directly whether intravascular air bubbles actually enlarge when highly soluble and diffusible gases are inspired, we used microscopy to measure the size of gas emboli in vivo. When air bubbles were injected into the right atrium, the bubbles that appeared in pulmonary arterioles were larger during ventilation with helium or nitrous oxide than with air. Air bubbles injected into the pulmonary artery enlarged when the inspired gas was changed to helium or nitrous oxide. The direction, magnitude, and timing of changes in bubble size were consistent with a net diffusion of gas into the bubbles. These data support the idea that venous air emboli enlarge during ventilation with soluble and diffusible gases and thereby cause further vascular obstruction.

Original languageEnglish
Pages (from-to)1068-1074
Number of pages7
JournalJournal of Applied Physiology
Volume70
Issue number3
StatePublished - 1991

Fingerprint

Embolism
Ventilation
Gases
Air
Helium
Nitrous Oxide
Air Embolism
Arterioles
Heart Atria
Pulmonary Hypertension
Pulmonary Artery
Blood Vessels
Microscopy
Hypertension
Lung

Keywords

  • dogs
  • helium
  • in vivo microscopy
  • molecular diffusion
  • nitrous oxide
  • precapillary gas exchange
  • pulmonary air embolism
  • surface tension
  • venous air embolism

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of ventilation with soluble and diffusible gases on the size of air emboli. / Presson, Robert; Kirk, K. R.; Haselby, K. A.; Wagner, W. W.

In: Journal of Applied Physiology, Vol. 70, No. 3, 1991, p. 1068-1074.

Research output: Contribution to journalArticle

Presson, Robert ; Kirk, K. R. ; Haselby, K. A. ; Wagner, W. W. / Effect of ventilation with soluble and diffusible gases on the size of air emboli. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 3. pp. 1068-1074.
@article{1a04f78573dc48f7808aa8315c08f4df,
title = "Effect of ventilation with soluble and diffusible gases on the size of air emboli",
abstract = "Pulmonary hypertension resulting from venous air embolism is known to increase after ventilation with highly soluble and diffusible gases. Exacerbation of the hypertension could be due to further blockage of the circulation if the bubbles enlarge as a result of ingress of gas by diffusion. This mechanism has been frequently cited but lacks direct proof. To determine directly whether intravascular air bubbles actually enlarge when highly soluble and diffusible gases are inspired, we used microscopy to measure the size of gas emboli in vivo. When air bubbles were injected into the right atrium, the bubbles that appeared in pulmonary arterioles were larger during ventilation with helium or nitrous oxide than with air. Air bubbles injected into the pulmonary artery enlarged when the inspired gas was changed to helium or nitrous oxide. The direction, magnitude, and timing of changes in bubble size were consistent with a net diffusion of gas into the bubbles. These data support the idea that venous air emboli enlarge during ventilation with soluble and diffusible gases and thereby cause further vascular obstruction.",
keywords = "dogs, helium, in vivo microscopy, molecular diffusion, nitrous oxide, precapillary gas exchange, pulmonary air embolism, surface tension, venous air embolism",
author = "Robert Presson and Kirk, {K. R.} and Haselby, {K. A.} and Wagner, {W. W.}",
year = "1991",
language = "English",
volume = "70",
pages = "1068--1074",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Effect of ventilation with soluble and diffusible gases on the size of air emboli

AU - Presson, Robert

AU - Kirk, K. R.

AU - Haselby, K. A.

AU - Wagner, W. W.

PY - 1991

Y1 - 1991

N2 - Pulmonary hypertension resulting from venous air embolism is known to increase after ventilation with highly soluble and diffusible gases. Exacerbation of the hypertension could be due to further blockage of the circulation if the bubbles enlarge as a result of ingress of gas by diffusion. This mechanism has been frequently cited but lacks direct proof. To determine directly whether intravascular air bubbles actually enlarge when highly soluble and diffusible gases are inspired, we used microscopy to measure the size of gas emboli in vivo. When air bubbles were injected into the right atrium, the bubbles that appeared in pulmonary arterioles were larger during ventilation with helium or nitrous oxide than with air. Air bubbles injected into the pulmonary artery enlarged when the inspired gas was changed to helium or nitrous oxide. The direction, magnitude, and timing of changes in bubble size were consistent with a net diffusion of gas into the bubbles. These data support the idea that venous air emboli enlarge during ventilation with soluble and diffusible gases and thereby cause further vascular obstruction.

AB - Pulmonary hypertension resulting from venous air embolism is known to increase after ventilation with highly soluble and diffusible gases. Exacerbation of the hypertension could be due to further blockage of the circulation if the bubbles enlarge as a result of ingress of gas by diffusion. This mechanism has been frequently cited but lacks direct proof. To determine directly whether intravascular air bubbles actually enlarge when highly soluble and diffusible gases are inspired, we used microscopy to measure the size of gas emboli in vivo. When air bubbles were injected into the right atrium, the bubbles that appeared in pulmonary arterioles were larger during ventilation with helium or nitrous oxide than with air. Air bubbles injected into the pulmonary artery enlarged when the inspired gas was changed to helium or nitrous oxide. The direction, magnitude, and timing of changes in bubble size were consistent with a net diffusion of gas into the bubbles. These data support the idea that venous air emboli enlarge during ventilation with soluble and diffusible gases and thereby cause further vascular obstruction.

KW - dogs

KW - helium

KW - in vivo microscopy

KW - molecular diffusion

KW - nitrous oxide

KW - precapillary gas exchange

KW - pulmonary air embolism

KW - surface tension

KW - venous air embolism

UR - http://www.scopus.com/inward/record.url?scp=0025965266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025965266&partnerID=8YFLogxK

M3 - Article

VL - 70

SP - 1068

EP - 1074

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -