Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass

George M. Eid, Daniel R. Cottam, Laura M. Velcu, Samer G. Mattar, Mary T. Korytkowski, Gabriella Gosman, Pooneh Hindi, Philip R. Schauer

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Purpose: Many women with polycystic ovarian syndrome (PCOS) are overweight. This study investigated the impact of weight loss surgery on the clinical manifestations of this disorder in morbidly obese women with PCOS-a major risk factor for the development of heart disease, stroke, and type II diabetes. Methods: We reviewed the outcomes of women diagnosed with PCOS who had undergone weight loss surgery at the University of Pittsburgh between July 1997 and November 2001. We evaluated the changes in menstrual cycles, hirsutism, infertility, and type II diabetes. Results: A total of 24 women with PCOS were included in the study. Their mean age was 34 ± 9.7 years. The mean preoperative body weight was 306 ± 44 lb, with a body mass index of 50 ± 7.5. All patients were oligomenorrheic. Of the 24 patients, 23 were hirsute. All women underwent elective laparoscopic gastric bypass surgery. The mean follow-up period was 27.5 ± 16 months. The mean excess weight loss at 1 year of follow-up was 56.7% ± 21.2%. All women resumed normal menstrual cycles after a mean of 3.4 ± 2.1 months postoperatively. Of the 23 women with hirsutism, 12 (52%) had complete resolution at a mean follow-up of 8 ± 2.3 months, 6 (25%) had moderate resolution at a mean of 21 ± 18 months, and 3 had minimal resolution at 34 ± 14 months. Two women reported no change in their hirsutism at 32 ± 7 months. Five women were able to conceive after surgery without the use of clomiphene. Conclusion: Gastric bypass surgery and its consequent weight loss results in significant improvement of multiple clinical problems related to PCOS.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalSurgery for Obesity and Related Diseases
Volume1
Issue number2
DOIs
StatePublished - Mar 2005
Externally publishedYes

Fingerprint

Gastric Bypass
Polycystic Ovary Syndrome
Hirsutism
Weight Loss
Therapeutics
Menstrual Cycle
Type 2 Diabetes Mellitus
Clomiphene
Infertility
Heart Diseases
Body Mass Index
Stroke
Body Weight

Keywords

  • Gastric bypass surgery
  • Laparoscopy
  • Obesity
  • Polycystic ovarian syndrome
  • Surgery
  • Treatment
  • Weight loss

ASJC Scopus subject areas

  • Surgery

Cite this

Eid, G. M., Cottam, D. R., Velcu, L. M., Mattar, S. G., Korytkowski, M. T., Gosman, G., ... Schauer, P. R. (2005). Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass. Surgery for Obesity and Related Diseases, 1(2), 77-80. https://doi.org/10.1016/j.soard.2005.02.008

Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass. / Eid, George M.; Cottam, Daniel R.; Velcu, Laura M.; Mattar, Samer G.; Korytkowski, Mary T.; Gosman, Gabriella; Hindi, Pooneh; Schauer, Philip R.

In: Surgery for Obesity and Related Diseases, Vol. 1, No. 2, 03.2005, p. 77-80.

Research output: Contribution to journalArticle

Eid, GM, Cottam, DR, Velcu, LM, Mattar, SG, Korytkowski, MT, Gosman, G, Hindi, P & Schauer, PR 2005, 'Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass', Surgery for Obesity and Related Diseases, vol. 1, no. 2, pp. 77-80. https://doi.org/10.1016/j.soard.2005.02.008
Eid, George M. ; Cottam, Daniel R. ; Velcu, Laura M. ; Mattar, Samer G. ; Korytkowski, Mary T. ; Gosman, Gabriella ; Hindi, Pooneh ; Schauer, Philip R. / Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass. In: Surgery for Obesity and Related Diseases. 2005 ; Vol. 1, No. 2. pp. 77-80.
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abstract = "Purpose: Many women with polycystic ovarian syndrome (PCOS) are overweight. This study investigated the impact of weight loss surgery on the clinical manifestations of this disorder in morbidly obese women with PCOS-a major risk factor for the development of heart disease, stroke, and type II diabetes. Methods: We reviewed the outcomes of women diagnosed with PCOS who had undergone weight loss surgery at the University of Pittsburgh between July 1997 and November 2001. We evaluated the changes in menstrual cycles, hirsutism, infertility, and type II diabetes. Results: A total of 24 women with PCOS were included in the study. Their mean age was 34 ± 9.7 years. The mean preoperative body weight was 306 ± 44 lb, with a body mass index of 50 ± 7.5. All patients were oligomenorrheic. Of the 24 patients, 23 were hirsute. All women underwent elective laparoscopic gastric bypass surgery. The mean follow-up period was 27.5 ± 16 months. The mean excess weight loss at 1 year of follow-up was 56.7{\%} ± 21.2{\%}. All women resumed normal menstrual cycles after a mean of 3.4 ± 2.1 months postoperatively. Of the 23 women with hirsutism, 12 (52{\%}) had complete resolution at a mean follow-up of 8 ± 2.3 months, 6 (25{\%}) had moderate resolution at a mean of 21 ± 18 months, and 3 had minimal resolution at 34 ± 14 months. Two women reported no change in their hirsutism at 32 ± 7 months. Five women were able to conceive after surgery without the use of clomiphene. Conclusion: Gastric bypass surgery and its consequent weight loss results in significant improvement of multiple clinical problems related to PCOS.",
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AB - Purpose: Many women with polycystic ovarian syndrome (PCOS) are overweight. This study investigated the impact of weight loss surgery on the clinical manifestations of this disorder in morbidly obese women with PCOS-a major risk factor for the development of heart disease, stroke, and type II diabetes. Methods: We reviewed the outcomes of women diagnosed with PCOS who had undergone weight loss surgery at the University of Pittsburgh between July 1997 and November 2001. We evaluated the changes in menstrual cycles, hirsutism, infertility, and type II diabetes. Results: A total of 24 women with PCOS were included in the study. Their mean age was 34 ± 9.7 years. The mean preoperative body weight was 306 ± 44 lb, with a body mass index of 50 ± 7.5. All patients were oligomenorrheic. Of the 24 patients, 23 were hirsute. All women underwent elective laparoscopic gastric bypass surgery. The mean follow-up period was 27.5 ± 16 months. The mean excess weight loss at 1 year of follow-up was 56.7% ± 21.2%. All women resumed normal menstrual cycles after a mean of 3.4 ± 2.1 months postoperatively. Of the 23 women with hirsutism, 12 (52%) had complete resolution at a mean follow-up of 8 ± 2.3 months, 6 (25%) had moderate resolution at a mean of 21 ± 18 months, and 3 had minimal resolution at 34 ± 14 months. Two women reported no change in their hirsutism at 32 ± 7 months. Five women were able to conceive after surgery without the use of clomiphene. Conclusion: Gastric bypass surgery and its consequent weight loss results in significant improvement of multiple clinical problems related to PCOS.

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