Effectiveness of antipsychotic treatment for schizophrenia: 6-Month results of the Pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study

Josep Maria Haro, E. T. Edgell, D. Novick, J. Alonso, L. Kennedy, P. B. Jones, M. Ratcliffe, A. Breier

Research output: Contribution to journalArticle

84 Scopus citations


Objective: To present the 6-month outcomes associated with antipsychotic treatment of patients participating in the Schizophrenia Outpatient Health Outcomes (SOHO) study. Method: SOHO is a 3-year, prospective, observational study of the health outcomes associated with antipsychotic treatment in 10 European countries. The study included over 10 000 out-patients who were initiating or changing their antipsychotic medication. Results: Clinical Global Impression (CGI)-severity and quality of life (QOL) scores improved in all treatment cohorts. There was a higher response in the CGI-overall symptoms and in the CGI-schizophrenia positive, negative, cognitive and depressive symptom scales in the olanzapine (Olz) and clozapine (Cloz) cohorts compared with other treatment cohorts. Changes were associated with an improvement in QOL. Conclusion: Patients starting Olz and Cloz tend to have better outcomes at 6 months than patients who start other antipsychotics in actual out-patient clinical practice. The results should be interpreted conservatively because of the non-randomized study design.

Original languageEnglish (US)
Pages (from-to)220-231
Number of pages12
JournalActa Psychiatrica Scandinavica
Issue number3
StatePublished - Mar 1 2005



  • Amisulpride
  • Antipsychotic agents
  • Clozapine
  • Olanzapine
  • Quetiapine
  • Risperidone
  • Schizophrenia
  • Treatment outcome

ASJC Scopus subject areas

  • Psychiatry and Mental health

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