Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

Jie Sun, Rajat Madan, Christopher L. Karp, Thomas J. Braciale

Research output: Contribution to journalArticle

351 Citations (Scopus)

Abstract

Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8+ and CD4+ effector T cells (Teff cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts - exclusively by infiltrating virus-specific Teff cells, with CD8+ Teff cells contributing a larger fraction of the IL-10 produced. These Teff cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the Teff cell-derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral Teff cells exert regulatory functions - that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses.

Original languageEnglish (US)
Pages (from-to)277-284
Number of pages8
JournalNature Medicine
Volume15
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Eragrostis
T-cells
Virus Diseases
Orthomyxoviridae
Viruses
Interleukin-10
Pneumonia
T-Lymphocytes
Antiviral Agents
Anti-Inflammatory Agents
Cytokines
Infection
Human Influenza
Tissue
Antigens
Wounds and Injuries
Lung Injury
Molecules
Inflammation
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. / Sun, Jie; Madan, Rajat; Karp, Christopher L.; Braciale, Thomas J.

In: Nature Medicine, Vol. 15, No. 3, 03.2009, p. 277-284.

Research output: Contribution to journalArticle

Sun, Jie ; Madan, Rajat ; Karp, Christopher L. ; Braciale, Thomas J. / Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. In: Nature Medicine. 2009 ; Vol. 15, No. 3. pp. 277-284.
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